INT176147

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.41
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
Anatomy Link Frequency
muscle 2
MDA-MB-468 2
MDA-MB-231 2
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 14 99.48 Very High Very High Very High
antagonist 2 97.80 Very High Very High Very High
Inflammation 100 90.76 High High
cytokine 93 84.20 Quite High
rheumatoid arthritis 77 80.96 Quite High
Arthritis 3 72.64 Quite High
pregabalin 1 58.40 Quite High
agonist 2 57.80 Quite High
Leflunomide 15 57.08 Quite High
metalloproteinase 7 56.56 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 122 99.84 Very High Very High Very High
Apoptosis 257 99.20 Very High Very High Very High
Pancreatic Cancer 50 98.96 Very High Very High Very High
Hemangiosarcoma 139 98.68 Very High Very High Very High
Glioma 26 97.64 Very High Very High Very High
Obesity 214 97.12 Very High Very High Very High
Bladder Cancer 32 97.04 Very High Very High Very High
Diabetes Mellitus 16 96.92 Very High Very High Very High
Endometrial Cancer 20 96.60 Very High Very High Very High
Disease 46 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The link between the action of HDAC inhibitors and the down-regulation of Akt phosphorylation has been reported previously [18,49,50].
Regulation (regulation) of Phosphorylation (phosphorylation) of Akt
1) Confidence 0.41 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.70 Pain Relevance 0
PTEN is a crucial phosphatase involved in the regulation of Akt phosphorylation: the presence of an active PTEN protein blocks Akt phosphorylation by the dephosphorylation of PI 3-K product, PIP3 [45].
Regulation (regulation) of Phosphorylation (phosphorylation) of Akt
2) Confidence 0.39 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.29 Pain Relevance 0.04
Another study, however, failed to detect any significant changes in the phosphorylation of Akt, mTOR, p70S6K, eEF2, eIF4E, and TSC2 in men following 10 and 21 d of ULS [26].
Regulation (changes) of Phosphorylation (phosphorylation) of Akt
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.21 Pain Relevance 0
We also assessed the phosphorylation status of Akt since its activity is regulated by phosphorylation [20,25].
Regulation (regulated) of Phosphorylation (phosphorylation) of Akt
4) Confidence 0.22 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.06 Pain Relevance 0
To asses whether the effect of AKT phosphorylation on Ser473 observed on cell lines grown in culture could be observed in the xenograft model, Western blot analysis was performed.
Regulation (effect) of Phosphorylation (phosphorylation) of AKT
5) Confidence 0.20 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.25 Pain Relevance 0
To explore whether inhibition of Akt activation may be the mechanism responsible for induction of apoptosis in MDA-MB-231 cells, we determined the effect of celecoxib on phosphorylation of Akt on breast cancer cell lines.
Spec (determined) Regulation (effect) of Phosphorylation (phosphorylation) of Akt in MDA-MB-231 associated with breast cancer and apoptosis
6) Confidence 0.17 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.79 Pain Relevance 0
mol/l, celecoxib treatment significantly (P = 0.002) downregulated the level of phosphorylation of Akt in MDA-MB-231 cells but not in MDA-MB-468 cells (Fig. 3a,b), suggesting that the mechanism of apoptosis induction in MDA-MB-231 cells was, in part, dependent upon decreased phosphorylation of Akt protein.
Regulation (dependent) of Phosphorylation (phosphorylation) of Akt in MDA-MB-468 associated with apoptosis
7) Confidence 0.17 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.75 Pain Relevance 0
However, if these functions occur in human muscle, then why the graded responses of phosphorylation of PKB or MAFbx do not result in graded reductions in LPB is puzzling.
Regulation (responses) of Phosphorylation (phosphorylation) of PKB in muscle
8) Confidence 0.15 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0.14 Pain Relevance 0.06
Notably, MTX treatment did reduce the levels of phosphorylation of AKT and STAT1.
Regulation (levels) of Phosphorylation (phosphorylation) of AKT associated with methotrexate
9) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.80 Pain Relevance 0.62
The mechanism for this inhibition involves regulating phosphorylation of specific cell signaling molecules (Akt, GSK3?
Regulation (regulating) of Phosphorylation (phosphorylation) of Akt
10) Confidence 0.11 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC3020166 Disease Relevance 0.17 Pain Relevance 0.03
However, AKT-independent and Cdk2-dependent phosphorylation affected FOXO1 nuclear export to different extents in U87 and U251 glioma cells [22].
Regulation (affected) of Phosphorylation (phosphorylation) of AKT associated with glioma
11) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.10 Pain Relevance 0
In conclusion, our research demonstrates for the first time that both constitutive and LN-induced FAK phosphorylation contribute to increased intrinsic chemoresistance to Gem in pancreatic cancer cell lines and these effects are partly due to the regulation of Akt and Bad phosphorylation and survivin expression.
Regulation (regulation) of Phosphorylation (phosphorylation) of Akt associated with pancreatic cancer
12) Confidence 0.08 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2806309 Disease Relevance 0.37 Pain Relevance 0
In this regard, mutations of the PI3K antagonist, PTEN, are common in canine hemangiosarcoma; however they are restricted to the C-terminal domain and do not affect the phosphorylation of Akt that occurs downstream from PI3K signaling [23].
Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of Akt associated with antagonist and hemangiosarcoma
13) Confidence 0.07 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2994824 Disease Relevance 1.07 Pain Relevance 0.18
Importantly, insulin effects on ERK1/2 (Fig. 3A and B) and on protein kinase B (PKB) phosphorylation were not modified (supplementary Fig.
Regulation (effects) of Phosphorylation (phosphorylation) of PKB
14) Confidence 0.04 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.38 Pain Relevance 0.10
Importantly, insulin effects on ERK1/2 (Fig. 3A and B) and on protein kinase B (PKB) phosphorylation were not modified (supplementary Fig.
Neg (not) Regulation (modified) of Phosphorylation (phosphorylation) of PKB
15) Confidence 0.04 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.32 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox