INT176149

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.63
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIB) signal transduction (NFKBIB) nucleus (NFKBIB)
cytoplasm (NFKBIB) signal transducer activity (NFKBIB)
NFKBIB (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 89 97.80 Very High Very High Very High
Inflammation 55 65.92 Quite High
cytokine 40 60.08 Quite High
cva 10 59.60 Quite High
agonist 7 50.00 Quite Low
peripheral neuropathy 12 21.72 Low Low
aspirin 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 65 98.60 Very High Very High Very High
Multiple Myeloma 46 92.32 High High
Cancer 38 85.76 High High
Pancreatic Cancer 21 80.40 Quite High
Solid Tumor 1 73.44 Quite High
Aggression 4 72.00 Quite High
Endometrial Cancer 20 68.48 Quite High
Adhesions 10 67.12 Quite High
INFLAMMATION 61 65.92 Quite High
Thrombosis 11 59.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P, phosphorylated protein; IkB, nuclear factor kB inhibitory protein
Phosphorylation (phosphorylated) of IkB
1) Confidence 0.16 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.49 Pain Relevance 0.03
Studies have shown that PTL targets NF-kB via inhibition of the upstream regulator IkB kinase (IKK) [17] which phosphorylates IkB and targets it for proteasomal degradation.
Phosphorylation (phosphorylates) of IkB
2) Confidence 0.15 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.83 Pain Relevance 0
Dominant negative Akt vector blocked IkB phosphorylation, which leads to the activation of apoptosis
Phosphorylation (phosphorylation) of IkB associated with apoptosis
3) Confidence 0.06 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.24 Pain Relevance 0
B phosphorylation and increases levels of IkB in HCEpiCs
Phosphorylation (phosphorylation) of IkB
4) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.07 Pain Relevance 0.35

General Comments

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