INT176150

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 63.04 Quite High
ischemia 36 50.00 Quite Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 20 97.84 Very High Very High Very High
INFLAMMATION 4 63.04 Quite High
Apoptosis 21 56.08 Quite High
Cv Unclassified Under Development 35 50.00 Quite Low
Stress 28 50.00 Quite Low
Cancer 22 5.00 Very Low Very Low Very Low
Hypoxia 6 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 2 5.00 Very Low Very Low Very Low
Colon Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of the other three sites appears not to be regulated (6, 9). 4E-BP1 is one of the main effectors of mammalian target of rapamycin (mTOR), serine/threonine-protein kinase in the phosphoinositide 3-kinase (PI3-kinase)/Akt (RAC serine/threonine-protein kinase, also named protein kinase B, PKB) signaling pathway that integrates signals from extracellular stimuli, amino acid availability, and oxygen and energy status of the cells (8). 4E-BPs contain a TOR signaling (TOS) motif that binds the mTOR complex 1 (mTORC1) (6). mTORC1 controls the activity of 4E-BP1.
Localization (target) of PI3-kinase
1) Confidence 0.73 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
The phosphoinositide 3-kinase (PI 3-kinase) pathway has been implicated in the activation of the proinflammatory transcription factor nuclear factor ?
Localization (implicated) of PI 3-kinase
2) Confidence 0.19 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.22 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox