INT176154

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 10.43
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
Anatomy Link Frequency
blood vessel 2
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 22 60.72 Quite High
chemokine 198 50.00 Quite Low
alcohol 2 35.88 Quite Low
antagonist 23 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
pain pelvic 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 497 100.00 Very High Very High Very High
Endometrial Cancer 791 99.60 Very High Very High Very High
Adenocarcinoma 38 99.56 Very High Very High Very High
Apoptosis 321 99.28 Very High Very High Very High
Microsatellite Instability 235 99.04 Very High Very High Very High
Ovarian Cancer 170 98.52 Very High Very High Very High
Cancer 795 97.44 Very High Very High Very High
Adhesions 10 95.08 Very High Very High Very High
Endometroid Carcinoma 105 94.16 High High
Hepatocellular Cancer 20 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, PIK3CA mRNA overexpression occurs in concert with p53 alterations only in nonendometrioid endometrial carcinomas [15].
Gene_expression (overexpression) of PIK3CA associated with endometrial cancer
1) Confidence 0.55 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.17 Pain Relevance 0
The tumors carrying exon 9 PIK3CA mutations are more likely to be low-grade carcinomas; in contrast, carcinomas with exon 20 mutations or PIK3CA mRNA overexpression are often high-grade carcinomas associated with myometrial invasion and tended to have lymphovascular invasion [15].
Gene_expression (overexpression) of PIK3CA associated with cancer and carcinoma
2) Confidence 0.55 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.11 Pain Relevance 0
PIK3CA mutations, particularly exon 20 mutations or PIK3CA mRNA overexpression, are frequent in endometrioid endometrial carcinoma in association with invasion and adverse prognostic factors such as blood vessel invasion [7, 15].

2.3.3.

Gene_expression (overexpression) of PIK3CA in blood vessel associated with endometrial cancer
3) Confidence 0.55 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.21 Pain Relevance 0
PIK3CA mutations, particularly exon 20 mutations or PIK3CA mRNA overexpression, are frequent in endometrioid endometrial carcinoma in association with invasion and adverse prognostic factors such as blood vessel invasion [7, 15].

2.3.3.

Gene_expression (overexpression) of PIK3CA in blood vessel associated with endometrial cancer
4) Confidence 0.48 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.24 Pain Relevance 0
PIK3CA mutations did not correlate with MSI or ?
Gene_expression (mutations) of PIK3CA associated with microsatellite instability
5) Confidence 0.48 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.20 Pain Relevance 0
Sensitizing HCC cells towards PI3K by specific downregulation of Mcl-1
Gene_expression (Sensitizing) of PI3K associated with carcinoma
6) Confidence 0.36 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.85 Pain Relevance 0
Furthermore, Mcl-1 downregulation further augmented apoptosis caused by combination therapy with PI3K inhibition and chemotherapeutics.
Neg (inhibition) Gene_expression (inhibition) of PI3K associated with apoptosis
7) Confidence 0.36 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.18 Pain Relevance 0
Mutations, amplification, and overexpression of well-known oncogenes, such as PI3K subunit-?
Gene_expression (overexpression) of PI3K
8) Confidence 0.36 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.03 Pain Relevance 0
In particular, EGFR and HER2/neu activate signaling pathways (PI3K/Akt and ERK1/2 MAP kinase), leading to different cellular processes involved in tumor development, such as cell division and migration, adhesion, differentiation, and apoptosis [58].
Gene_expression (/) of PI3K associated with cancer, apoptosis and adhesions
9) Confidence 0.31 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.23 Pain Relevance 0
The phosphoinositide 3-kinase (PI 3-kinase) pathway has been implicated in the activation of the proinflammatory transcription factor nuclear factor ?
Gene_expression (The) of PI 3-kinase
10) Confidence 0.17 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.21 Pain Relevance 0.03

General Comments

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