INT176173

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Context Info
Confidence 0.52
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 10.95
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1h2) DNA binding (Nr1h2) cytoplasm (Nr1h2)
Anatomy Link Frequency
macrophages 2
liver 1
pancreas 1
Adipocyte 1
Nr1h2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 101 99.76 Very High Very High Very High
cytokine 29 99.62 Very High Very High Very High
metalloproteinase 2 99.14 Very High Very High Very High
Bile 444 93.92 High High
Inflammation 146 93.88 High High
Arthritis 2 21.12 Low Low
nud 20 5.00 Very Low Very Low Very Low
tolerance 19 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 13 99.92 Very High Very High Very High
Repression 60 99.58 Very High Very High Very High
Apoptosis 64 99.20 Very High Very High Very High
Hyperglycemia 31 99.08 Very High Very High Very High
Insulin Resistance 54 98.96 Very High Very High Very High
Disorder Of Lipid Metabolism 825 97.48 Very High Very High Very High
Aging 70 96.16 Very High Very High Very High
Metabolic Disorder 10 95.92 Very High Very High Very High
Disease 67 94.24 High High
INFLAMMATION 163 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the contrary some evidence have shown that chronic LXR activation is known to induce apoptosis in different cells line e.g. pancreatic ?
Positive_regulation (activation) of LXR associated with apoptosis
1) Confidence 0.52 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 1.38 Pain Relevance 0.21
LXR is activated by natural oxysterols, such as 22(R)-hydroxycholesterol, 24,25(S)-epoxycholesterol, and 27-hydroxycholesterol, and the synthetic compound T0901317 [2], and regulates the intracellular levels of cholesterol through gene induction of enzymes and proteins involved in the cholesterol metabolism and transport [3].
Positive_regulation (activated) of LXR
2) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.25 Pain Relevance 0.05
But when given liver X receptor alpha (LXR?)
Positive_regulation (liver) of LXR in liver
3) Confidence 0.34 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0 Pain Relevance 0.05
The mechanism of this inhibitory action is unknown, and thus far no LXR response elements have been identified on the ptp1b promoter, although the expression of other genes such as matrix metalloproteinase-9, induced by cytokines, was repressed by LXR activation in macrophages (50).
Positive_regulation (activation) of LXR in macrophages associated with metalloproteinase and cytokine
4) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.59 Pain Relevance 0.32
mediate activation of the LXR/RXR heterodimer, which in turn regulates cholesterol efflux via ABCA1 and ABCG1 activation (Schmitz et al 2002).
Positive_regulation (activation) of LXR
5) Confidence 0.21 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.67 Pain Relevance 0.17
Explaining some of the BAS metabolic effects through increased LXR activity has appeal because LXR agonists are known to lower glucose, lower LDL-C, and raise HDL-C levels (Laffitte et al 2003; Tontonoz and Mangelsdorf 2003).
Positive_regulation (increased) of LXR associated with agonist and disorder of lipid metabolism
6) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.60 Pain Relevance 0.09
Therefore, if direct effects of FXR repression from BAS do indeed promote hyperglycemia, this effect may be overcome by the indirect increase in LXR activity, resulting in a net decrease in glucose levels.
Positive_regulation (increase) of LXR associated with hyperglycemia and repression
7) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.56 Pain Relevance 0.11
Nevertheless, while the glucose-lowering effect of BAS is not entirely clear, increased LXR activity from BAS may represent a unifying explanation as to why BAS may decrease glucose, increase HDL-C, and increase TG levels (Bays and Cohen 2007).


Positive_regulation (increased) of LXR associated with disorder of lipid metabolism
8) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.23 Pain Relevance 0.06
Specifically, increased LXR activity increases adipogenesis through increased expression of Adipocyte Determination and Differentiation-dependent Factor 1/Sterol Regulatory Element Binding Protein 1c, FAS genes, peroxisome proliferators-activated receptor gamma, and adipose protein 2 (Seo et al 2004).
Positive_regulation (increased) of LXR in Adipocyte
9) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.54 Pain Relevance 0.03
Thus, if increased LXR activity is an important mechanism of action accounting for BAS metabolic effects, then not only would this explain the glucose-lowering effects of BAS, but would also explain the variable increase in both HDL-C and TG levels observed with BAS (Bays and Cohen 2007).
Positive_regulation (increased) of LXR associated with disorder of lipid metabolism
10) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.42 Pain Relevance 0.09
Increased LXR activity may also suppress hepatic gluconeogenesis, improve hepatic glucose utilization, and increase hepatic glucose uptake.
Positive_regulation (Increased) of LXR
11) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.52 Pain Relevance 0.04
The major difference between these two libraries was found downstream LXR activation.
Positive_regulation (activation) of LXR
12) Confidence 0.15 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.68 Pain Relevance 0.07
Thus, this indirect effect of FXR repression would be a relative increase in hepatic LXR activity, which downregulates enzymes that may contribute to hepatic insulin resistance and glucose intolerance.
Positive_regulation (increase) of LXR associated with repression, insulin resistance and impaired glucose tolerance
13) Confidence 0.14 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.59 Pain Relevance 0.05
Circulating concentrations of IGF-BP2 are known to be inversely related to GH status [38] and were significantly upregulated in progeroid NER mice, further underlining the downregulation of the somatotropic axis.
Positive_regulation (upregulated) of progeroid NER
14) Confidence 0.12 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.29 Pain Relevance 0
They have the potential of raising HDL levels because they up-regulate the ABCA-1 and ABCG-1 receptors in the macrophages that promote RCT.57 Thiazolidinediones are molecules that activate LXR-?
Positive_regulation (activate) of LXR in macrophages associated with disorder of lipid metabolism
15) Confidence 0.11 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.98 Pain Relevance 0.37
Among the glucose-related effects of LXR activity are an increase in insulin secretion from the pancreas (Efanov et al 2004), and increased adipogenesis (Seo et al 2004).
Positive_regulation (increase) of LXR in pancreas
16) Confidence 0.11 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.59 Pain Relevance 0.03
One of the important indirect effects of FXR activation relates to LXR.
Positive_regulation (activation) of LXR
17) Confidence 0.11 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.51 Pain Relevance 0.03
Specifically, increased LXR activity downregulates 11 beta-hydroxysteroid dehydrogenase type 1 (Stulnig et al 2002), downregules PPAR gamma, coactivator-1 alpha, and gluconeogenic enzymes such as PEPCK and glucose-6-phosphatase (Cao et al 2003; Laffitte et al 2003) and increases expression of glucokinase and GLUT-4 (Laffitte et al 2003).
Positive_regulation (increased) of LXR
18) Confidence 0.11 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.51 Pain Relevance 0.04
Taken together, these data suggest that defects particularly in transcription-coupled NER are not growth limiting in proliferating cells.
Positive_regulation (coupled) of NER
19) Confidence 0.10 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.99 Pain Relevance 0.07

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