INT176175

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.59
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcg8) ATPase activity (Abcg8)
Anatomy Link Frequency
Plasma 2
Abcg8 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 215 82.48 Quite High
agonist 15 57.12 Quite High
anesthesia 10 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 190 100.00 Very High Very High Very High
Disease 30 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 25 5.00 Very Low Very Low Very Low
Body Weight 15 5.00 Very Low Very Low Very Low
Stroke 15 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Coronary Artery Disease 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Lipidosis 5 5.00 Very Low Very Low Very Low
Dislocations 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma and hepatic plant sterol levels in Abcg8-/- and Abcg5/Abcg8 knockout are increased similarly with marked decreases in cholesterol levels.
Positive_regulation (increased) of Abcg8 in Plasma associated with targeted disruption
1) Confidence 0.70 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.24 Pain Relevance 0.21
Plasma and hepatic plant sterol levels in Abcg8-/- and Abcg5/Abcg8 knockout are increased similarly with marked decreases in cholesterol levels.
Positive_regulation (increased) of Abcg8 in Plasma associated with targeted disruption
2) Confidence 0.70 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.24 Pain Relevance 0.21
Plant sterols were almost undetectable in wild-type and heterozygous mice, but were significantly elevated in Abcg8-/- mice.
Positive_regulation (elevated) of Abcg8
3) Confidence 0.50 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0 Pain Relevance 0
These data strongly support the direct role of Abcg8/sterolin-2 as a key player in biliary cholesterol secretion, although biliary sitosterol secretion was apparently preserved.
Positive_regulation (role) of Abcg8
4) Confidence 0.50 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.06 Pain Relevance 0.14
These data strongly support the direct role of Abcg8/sterolin-2 as a key player in biliary cholesterol secretion, although biliary sitosterol secretion was apparently preserved.
Positive_regulation (role) of sterolin
5) Confidence 0.50 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.06 Pain Relevance 0.14

General Comments

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