INT176177

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Context Info
Confidence 0.81
First Reported 2004
Last Reported 2004
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 16
Disease Relevance 3.79
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcg8) ATPase activity (Abcg8)
Anatomy Link Frequency
bile 7
enterocytes 1
epithelial cells 1
Abcg8 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 688 100.00 Very High Very High Very High
agonist 48 86.88 High High
anesthesia 32 5.00 Very Low Very Low Very Low
isoflurane 16 5.00 Very Low Very Low Very Low
Arthritis 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 608 99.84 Very High Very High Very High
Disease 96 95.32 Very High Very High Very High
Body Weight 48 74.24 Quite High
Disorder Of Lipid Metabolism 80 39.92 Quite Low
Sprains And Strains 16 16.96 Low Low
Stroke 48 5.00 Very Low Very Low Very Low
Coronary Artery Disease 16 5.00 Very Low Very Low Very Low
Arthritis 16 5.00 Very Low Very Low Very Low
Lipidosis 16 5.00 Very Low Very Low Very Low
Dislocations 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biliary secretion of bile salts, sterol and phospholipids in Abcg8/sterolin-2 deficient mice
Localization (secretion) of sterolin in bile associated with bile
1) Confidence 0.81 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.53 Pain Relevance 0.21
Interestingly, in a report of Abcg5/Abcg8 localization in canine gallbladder epithelial cells, these two proteins were found intracellularly under baseline conditions [44].
Localization (localization) of Abcg8 in epithelial cells
2) Confidence 0.81 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0 Pain Relevance 0.04
Biliary secretion of bile salts, sterol and phospholipids in Abcg8/sterolin-2 deficient mice
Localization (secretion) of Abcg8 in bile associated with bile
3) Confidence 0.81 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.53 Pain Relevance 0.21
The ability of Abcg8-/- mice to secrete bile salt and phospholipid into bile as compared to wild-type mice was not significantly impaired.
Localization (secrete) of Abcg8 in bile associated with bile
4) Confidence 0.81 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.20 Pain Relevance 0.30
Serial sections of intestinal tissue were incubated with anti-Abcg5/sterolin-1 to determine the cellular location of Abcg5/sterolin-1.
Spec (determine) Localization (location) of sterolin
5) Confidence 0.75 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.12 Pain Relevance 0
Measurement of biliary sterol secretion rates in Abcg8-/- mice demonstrated a failure to increase sterol secretion into bile despite exogenous infusion of bile acids.
Localization (secretion) of Abcg8 in bile associated with bile
6) Confidence 0.75 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.22 Pain Relevance 0.21
Localization of Abcg5 protein in Abcg8-/- knockout mice
Localization (Localization) of Abcg8 associated with targeted disruption
7) Confidence 0.75 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.41 Pain Relevance 0
Despite this reservation, the finding that sitosterol is present in the bile suggests that plant sterols may be secreted independent of Abcg8/sterolin-2.
Localization (secreted) of Abcg8 in bile associated with bile
8) Confidence 0.71 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.20 Pain Relevance 0.30
These data strongly support the direct role of Abcg8/sterolin-2 as a key player in biliary cholesterol secretion, although biliary sitosterol secretion was apparently preserved.
Localization (secretion) of Abcg8
9) Confidence 0.71 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.07 Pain Relevance 0.20
Since the Abcg8-/- mice still secreted some sterols we were interested in which biliary sterol species were being secreted.
Localization (secreted) of Abcg8
10) Confidence 0.71 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.39 Pain Relevance 0.14
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol

Background

Localization (secrete) of sterolin
11) Confidence 0.71 Published 2004 Journal BMC Med Section Title Doc Link PMC394351 Disease Relevance 0.20 Pain Relevance 0
In addition, we report studies of biliary sterol secretion that show that despite forced secretion, Abcg8-deficient animals cannot secrete cholesterol into bile, although sitosterol secretion seemed unaffected.


Neg (cannot) Localization (secrete) of Abcg8-deficient in bile associated with bile
12) Confidence 0.71 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.32 Pain Relevance 0.05
The pattern of staining of Abcg5/sterolin-1 in the intestinal sections is clearly apical and localized to the villi of the enterocytes (Figure 6g,6h,6i).
Localization (localized) of sterolin in enterocytes
13) Confidence 0.71 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.12 Pain Relevance 0
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol

Background

Localization (secrete) of Abcg8
14) Confidence 0.71 Published 2004 Journal BMC Med Section Title Doc Link PMC394351 Disease Relevance 0.20 Pain Relevance 0
Despite this reservation, the finding that sitosterol is present in the bile suggests that plant sterols may be secreted independent of Abcg8/sterolin-2.
Localization (secreted) of sterolin in bile associated with bile
15) Confidence 0.71 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.21 Pain Relevance 0.30
These data strongly support the direct role of Abcg8/sterolin-2 as a key player in biliary cholesterol secretion, although biliary sitosterol secretion was apparently preserved.
Localization (secretion) of sterolin
16) Confidence 0.31 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.07 Pain Relevance 0.20

General Comments

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