INT176182

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.49
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb4) ATPase activity (Abcb4) transmembrane transport (Abcb4)
Anatomy Link Frequency
bile 2
livers 1
Abcb4 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 59 100.00 Very High Very High Very High
Inflammation 2 14.08 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 38 73.76 Quite High
Disorder Of Lipid Metabolism 27 59.04 Quite High
Cardiovascular Disease 8 50.44 Quite High
Atherosclerosis 4 49.52 Quite Low
INFLAMMATION 4 14.08 Low Low
Stress 4 11.92 Low Low
Disease 6 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Judged by the plasma lathosterol to cholesterol ratio, endogenous cholesterol synthesis was increased in exercising mice (0.15 ± 0.03 vs. 0.11 ± 0.02, p < 0.05), while the hepatic mRNA expression of key transporters for biliary cholesterol (Abcg5/g8, Sr-bI) as well as bile acid (Abcb11) and phospholipd (Abcb4) excretion did not change.
Transcription (expression) of Abcb4 in bile associated with bile
1) Confidence 0.43 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2903598 Disease Relevance 0.05 Pain Relevance 0.13
In support of these physiological data, also the mRNA expression of several transporters critical for the biliary secretion of cholesterol (Abcg5/g8, Sr-bI), bile acids (Abcb11) and phospholipids (Abcb4) remained unchanged (table 2).
Transcription (expression) of Abcb4 in bile associated with bile
2) Confidence 0.38 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2903598 Disease Relevance 0.17 Pain Relevance 0.14
To investigate the effects of a deficiency of Abcg8/sterolin-2 on the genes that regulate sterol metabolism, quantitative RT-PCR was performed looking at the expression levels of Abcg5, Abcg8, Hmgr, Cyp7a1, Abca1, Mdr2, Lxr, Srebp-1c, and Srebp-2 mRNA in the livers of mice fed a regular chow diet (Figure 4a).
Transcription (levels) of Mdr2 in livers
3) Confidence 0.18 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.27 Pain Relevance 0

General Comments

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