INT17619

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1991
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 12
Total Number 18
Disease Relevance 8.46
Pain Relevance 12.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT)
plasma membrane (COMT) cytoplasm (COMT)
Anatomy Link Frequency
brain 2
RBCs 1
COMT (Homo sapiens)
COMT - V158M (1)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 917 100.00 Very High Very High Very High
Enkephalin 10 100.00 Very High Very High Very High
Pain 562 99.96 Very High Very High Very High
dopamine receptor 7 99.80 Very High Very High Very High
opioid receptor 6 99.68 Very High Very High Very High
Dismenorea 4 99.58 Very High Very High Very High
Anterior cingulate cortex 165 99.48 Very High Very High Very High
imagery 63 94.92 High High
Dopamine 48 94.84 High High
insula 35 93.88 High High
Disease Link Frequency Relevance Heat
Pain 539 99.96 Very High Very High Very High
Anxiety Disorder 218 99.64 Very High Very High Very High
Hantavirus Infection 236 99.60 Very High Very High Very High
Dysmenorrhea 4 99.58 Very High Very High Very High
Pre-term Labor 4 96.64 Very High Very High Very High
Cognitive Disorder 50 94.68 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 45 90.84 High High
Cancer 20 83.36 Quite High
Urological Neuroanatomy 6 82.96 Quite High
Nicotine Addiction 5 82.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure.
Regulation (modulate) of catechol-O-methyltransferase associated with pain and catechol-o-methyltransferase
1) Confidence 0.45 Published 2006 Journal Science Section Title Doc Link 17185601 Disease Relevance 0.28 Pain Relevance 0.60
In Fig. 2 the effect of COMT genotype on ACC activation is shown.
Regulation (effect) of COMT associated with catechol-o-methyltransferase and anterior cingulate cortex
2) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2887789 Disease Relevance 0.14 Pain Relevance 0.73
Collectively, these findings provide a preliminary model of differential susceptibility to sexual risk behavior via executive dysfunction, dependent on COMT genotype, particularly the Met/Met genotype (Figure 1).
Regulation (dependent) of COMT
3) Confidence 0.45 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.15 Pain Relevance 0
This differentiation of dopamine receptor activity dependent on COMT genotype has led to several investigations into the relationship between COMT and executive dysfunction in which the Val allele has been putatively linked to poor performance on executive functioning tasks [21].
Regulation (dependent) of COMT associated with dopamine receptor
4) Confidence 0.45 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.06 Pain Relevance 0.30
-dependent down-regulation of COMT was not due to cytotoxic effects as more than 95% of cells treated with TNF?
Regulation (regulation) of COMT associated with catechol-o-methyltransferase
5) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.12 Pain Relevance 0.67
The COMT val158met polymorphism may affect pain processing in several ways.
Spec (may) Regulation (affect) of COMT val158met (V158M) associated with pain and catechol-o-methyltransferase
6) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2887789 Disease Relevance 0.79 Pain Relevance 1.52
The general linear model (GLM) multivariate analysis of variance (MANOVA) revealed a statistically significant COMT genotype effect on BOLD activation across the four ROIs (F = 2.794, df = 4, p = 0.035).
Regulation (effect) of COMT associated with catechol-o-methyltransferase
7) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2887789 Disease Relevance 0.20 Pain Relevance 0.92
We observed an effect of COMT genotype on brain activation in the absence of any behavioral effects (subjective pain ratings).
Regulation (effect) of COMT in brain associated with pain and catechol-o-methyltransferase
8) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2887789 Disease Relevance 0.87 Pain Relevance 1.50
An effect of COMT genotype on phasic pain has not been reported so far.
Regulation (effect) of COMT associated with pain and catechol-o-methyltransferase
9) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2887789 Disease Relevance 1.34 Pain Relevance 1.59
COMT Val108/158Met genotype affects the mu-opioid receptor system in the human brain: evidence from ligand-binding, G-protein activation and preproenkephalin mRNA expression.
Regulation (affects) of COMT in brain associated with enkephalin and opioid receptor
10) Confidence 0.39 Published 2005 Journal Neuroimage Section Title Doc Link 16040257 Disease Relevance 0.08 Pain Relevance 0.91
Using quantitative real-time RT-PCR analysis, we further demonstrated a down-regulation of MB-COMT mRNA at 0.5 h and 30 h following TNF?
Regulation (regulation) of MB-COMT mRNA associated with catechol-o-methyltransferase
11) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.50 Pain Relevance 0.75
Consequent deletions of 5'fragments led to a graduate increase in overall basal promoter activity in all constructs, suggesting the presence of serial putative negatively regulating elements along the P2-COMT promoter.
Regulation (regulating) of P2-COMT associated with catechol-o-methyltransferase
12) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.08 Pain Relevance 0.31
Taken together, these results suggest that the synonymous and nonsynonymous minor SNPs tested herein do not significantly alter functional effects on COMT enzymatic activity produced by the met158 allele associated with the APS haplotype and the mRNA secondary structure associated with the HPS haplotype and, thus, can be considered neutral.


Neg (not) Regulation (alter) of COMT associated with catechol-o-methyltransferase and hantavirus infection
13) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.67 Pain Relevance 0.12
A single nucleotide polymorphism (SNP) in codon 158 (val(158)met), which affects COMT protein stability, has been associated with the human experience of pain.
Regulation (affects) of COMT associated with pain and catechol-o-methyltransferase
14) Confidence 0.24 Published 2006 Journal Pain Section Abstract Doc Link 16837133 Disease Relevance 0.48 Pain Relevance 0.71
To ascertain whether uterine contractions are associated with changes in COMT activity in red blood cells (RBCs), we studied 25 women with established threat of preterm labor between 25 and 33 weeks of gestation, 25 gestational age-matched control women not experiencing uterine contractions, 25 women who were in term labor, and 25 non-pregnant healthy women.
Spec (whether) Regulation (changes) of COMT in RBCs associated with catechol-o-methyltransferase, dismenorea and pre-term labor
15) Confidence 0.24 Published 1991 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 1927294 Disease Relevance 0.50 Pain Relevance 0.57
Effect of minor SNPs on COMT RNA abundance, protein expression, and enzymatic activity
Regulation (Effect) of COMT associated with catechol-o-methyltransferase
16) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.88 Pain Relevance 0.08
Results from in silico and in vitro experiments revealed that inclusion of allelic variants of these minor SNPs in APS or HPS haplotypes did not modify COMT function at the level of mRNA folding, RNA transcription, protein translation, or enzymatic activity.
Neg (not) Regulation (modify) of COMT associated with catechol-o-methyltransferase and hantavirus infection
17) Confidence 0.24 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2664927 Disease Relevance 0.73 Pain Relevance 0.51
A polymorphism in the human COMT gene (G472A) results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met) and also reduces the activity of the enzyme to one quarter of that encoded by the Val allele.79 The alleles are codominant, and heterozygotic patients (Val/Met genotype) have intermediate levels of COMT activity in comparison to homozygous individuals.80 There have been several studies about the possible role of the COMT gene in OCD.
Spec (possible) Regulation (role) of COMT associated with catechol-o-methyltransferase and anxiety disorder
18) Confidence 0.19 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.62 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox