INT176199

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcg8) ATPase activity (Abcg8)
Abcg8 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 65.32 Quite High
Bile 86 44.44 Quite Low
Arthritis 2 17.64 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 76 99.76 Very High Very High Very High
Disorder Of Lipid Metabolism 10 94.44 High High
Disease 12 77.08 Quite High
Sprains And Strains 2 46.88 Quite Low
Increased Venous Pressure Under Development 2 18.88 Low Low
Arthritis 2 17.64 Low Low
Arthralgia 2 17.20 Low Low
Xanthomatosis 2 15.88 Low Low
Lipidosis 2 8.40 Low Low
Body Weight 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exact function of these two proteins still remains unknown but recent studies have shown that overexpression of ABCG5/ABCG8 in a transgenic mouse model results in an increased biliary cholesterol concentration and a 50% reduction in the fractional absorption of dietary cholesterol [17].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ABCG8 associated with targeted disruption and disorder of lipid metabolism
1) Confidence 0.50 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.34 Pain Relevance 0.03
It has been shown that Abcg8/sterolin-2 expression is required for correct apical trafficking of Abcg5/sterolin-1 to the apical surface in a polarized cell line and more recently in vivo by over-expression experiments [18,19].
Positive_regulation (required) of Gene_expression (expression) of sterolin
2) Confidence 0.47 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0 Pain Relevance 0

General Comments

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