INT176202

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.25
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb4) ATPase activity (Abcb4) transmembrane transport (Abcb4)
Anatomy Link Frequency
livers 1
Abcb4 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 147 92.84 High High
agonist 35 88.72 High High
Inflammation 20 42.80 Quite Low
adenocard 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
Endocannabinoid 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gallstones 249 99.12 Very High Very High Very High
Syndrome 96 98.92 Very High Very High Very High
Disease 37 98.92 Very High Very High Very High
Iron Overload 3 98.48 Very High Very High Very High
Hepatitis 10 97.00 Very High Very High Very High
Liver Disease 21 95.92 Very High Very High Very High
Hepatitis C Virus Infection 12 94.40 High High
Hepatitis B Virus Infection 11 94.12 High High
Recurrence 36 92.56 High High
Targeted Disruption 53 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical phenotype associated with ABCB4 gene mutations
Gene_expression (mutations) of ABCB4 gene
1) Confidence 0.68 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 1.78 Pain Relevance 0
Characterization of the ABCB4 gene mutations in patients with the LPAC syndrome
Gene_expression (mutations) of ABCB4 gene associated with syndrome and gallstones
2) Confidence 0.68 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 1.31 Pain Relevance 0
Drugs that may induce ABCB4 expression.


Gene_expression (expression) of ABCB4
3) Confidence 0.60 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 1.62 Pain Relevance 0.16
To investigate the effects of a deficiency of Abcg8/sterolin-2 on the genes that regulate sterol metabolism, quantitative RT-PCR was performed looking at the expression levels of Abcg5, Abcg8, Hmgr, Cyp7a1, Abca1, Mdr2, Lxr, Srebp-1c, and Srebp-2 mRNA in the livers of mice fed a regular chow diet (Figure 4a).
Gene_expression (expression) of Mdr2 in livers
4) Confidence 0.59 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.27 Pain Relevance 0
stimulates expression of the hepatobiliary phospholipid transporter Abcb4 [24, 62, 94, 144].

9.

Gene_expression (expression) of Abcb4
5) Confidence 0.20 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0 Pain Relevance 0.23
Fibrates upregulate mdr2 gene expression [70], which is associated with an increase in biliary phospholipid secretion [71].
Gene_expression (expression) of mdr2 gene
6) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.27 Pain Relevance 0.13

General Comments

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