INT176205

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 2.50
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp7a1) endoplasmic reticulum (Cyp7a1) lipid metabolic process (Cyp7a1)
Anatomy Link Frequency
bile 5
liver 2
Cyp7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 275 99.88 Very High Very High Very High
agonist 149 99.84 Very High Very High Very High
Spinal cord 2 50.56 Quite High
Inflammation 90 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Endocannabinoid 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 222 98.32 Very High Very High Very High
Disorder Of Lipid Metabolism 79 74.04 Quite High
Toxicity 10 72.60 Quite High
Heart Defects 2 71.28 Quite High
Hepatotoxicity 4 55.72 Quite High
Colon Cancer 8 41.80 Quite Low
Liver Disease 6 41.12 Quite Low
Obesity 90 28.64 Quite Low
Body Weight 9 26.04 Quite Low
Osteoporosis 14 23.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Fgf15 suppresses the expression of Cyp7a1 in the liver by activating the ?
Gene_expression (expression) of Cyp7a1 in liver
1) Confidence 0.69 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.20 Pain Relevance 0.24
To investigate the effects of a deficiency of Abcg8/sterolin-2 on the genes that regulate sterol metabolism, quantitative RT-PCR was performed looking at the expression levels of Abcg5, Abcg8, Hmgr, Cyp7a1, Abca1, Mdr2, Lxr, Srebp-1c, and Srebp-2 mRNA in the livers of mice fed a regular chow diet (Figure 4a).
Gene_expression (expression) of Cyp7a1 in livers
2) Confidence 0.61 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.26 Pain Relevance 0
-hydroxylase (Cyp7a1) gene expression is increased in the surviving mice.
Gene_expression (expression) of Cyp7a1
3) Confidence 0.60 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.45 Pain Relevance 0.18
In contrast, although the Cyp7a1 mRNA expression levels were essentially unchanged in the knockout mouse, Cyp7a1 activity was significantly decreased by 37% (P < 0.01).
Gene_expression (expression) of Cyp7a1 associated with targeted disruption
4) Confidence 0.53 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.39 Pain Relevance 0
Additionally, the activity of the rate-limiting enzyme for bile acid synthesis, CYP7a1, is reduced, although no changes at the mRNA level are noted.
Gene_expression (synthesis) of CYP7a1 in bile associated with bile
5) Confidence 0.48 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.17 Pain Relevance 0.14
Activation of SXR downregulated expression of CYP7A1, the first and rate limiting step in the metabolism of cholesterol to bile acids [Staudinger et al., 2001; Xie et al., 2001].
Gene_expression (expression) of CYP7A1 in bile associated with bile
6) Confidence 0.39 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.36 Pain Relevance 0.36
Bile acid activated FXR represses the expression of CYP7A1 and CYP2B, enzymes involved in bile acid synthesis, through an indirect mechanism.
Gene_expression (expression) of CYP7A1 in bile associated with bile
7) Confidence 0.39 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.14 Pain Relevance 0.23
agonists reduce Cyp7a1 expression in both mice and human [145, 238–240].
Gene_expression (7a1 expres) of Cyp7a1 associated with agonist
8) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.13 Pain Relevance 0.35
Expression of Cyp7a1, which represents the rate-limiting enzyme in bile acid synthesis, is markedly downregulated in PPAR??
Gene_expression (Expression) of Cyp7a1 in bile associated with bile
9) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.15 Pain Relevance 0.30
Expression of Cyp7a1, which represents the rate-limiting enzyme in bile acid synthesis, is markedly downregulated in PPAR??
Gene_expression (Expression) of Cyp7a1 in bile associated with bile
10) Confidence 0.29 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.15 Pain Relevance 0.30
To what extent the changes in Cyp7a1 expression reflect direct regulation by PPAR?
Gene_expression (expression) of Cyp7a1
11) Confidence 0.29 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.12 Pain Relevance 0.35

General Comments

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