INT176208

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 22.75
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1h2) DNA binding (Nr1h2) cytoplasm (Nr1h2)
Anatomy Link Frequency
liver 7
lung 3
macrophages 2
plasma 1
CAR 1
Nr1h2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 396 100.00 Very High Very High Very High
agonist 230 100.00 Very High Very High Very High
Bile 112 98.56 Very High Very High Very High
cytokine 50 94.80 High High
metalloproteinase 4 93.84 High High
Inflammatory response 36 93.40 High High
psoriasis 63 87.84 High High
COX2 10 87.20 High High
cINOD 12 46.24 Quite Low
ischemia 9 41.88 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 420 100.00 Very High Very High Very High
Syndrome 103 100.00 Very High Very High Very High
Targeted Disruption 151 99.70 Very High Very High Very High
Disease 114 99.32 Very High Very High Very High
Atherosclerosis 268 99.16 Very High Very High Very High
Death 135 99.00 Very High Very High Very High
Cockayne Syndrome 122 98.36 Very High Very High Very High
Nicotine Addiction 254 98.12 Very High Very High Very High
Lung Injury 15 97.44 Very High Very High Very High
Disorder Of Lipid Metabolism 1505 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, recently it has been demonstrated the expression of LXR in alveolar macrophages, alveolar type II cells, and PMNs and proceed to show potent anti-inflammatory and ant host defense effects of synthetic LXR agonists in the lung [10].
Gene_expression (expression) of LXR in lung associated with inflammation and agonist
1) Confidence 0.59 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.55 Pain Relevance 0.27
the expression of the liver X-receptor

(LXR), an oxysterol-activated nuclear hormone receptor that increases

Gene_expression (expression) of LXR in liver
2) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.72 Pain Relevance 0.15
To investigate the effects of a deficiency of Abcg8/sterolin-2 on the genes that regulate sterol metabolism, quantitative RT-PCR was performed looking at the expression levels of Abcg5, Abcg8, Hmgr, Cyp7a1, Abca1, Mdr2, Lxr, Srebp-1c, and Srebp-2 mRNA in the livers of mice fed a regular chow diet (Figure 4a).
Gene_expression (expression) of Lxr in livers
3) Confidence 0.53 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.27 Pain Relevance 0
But when given liver X receptor alpha (LXR?)
Gene_expression (given) of LXR in liver
4) Confidence 0.46 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0 Pain Relevance 0.05
In particular, we demonstrated that the treatment with T0901317 lowers the signal for Bax in treated group when compared with lung sections obtained from carrageenan-treated mice; while on the contrary, the signal is much more express for Bcl-2 in the LXR agonist T0901317 treated mice than in carrageenan-treated mice.
Gene_expression (express) of LXR in lung associated with agonist
5) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 1.24 Pain Relevance 0.31
Moreover, recent evidence have also clearly demonstrated that endogenous LXR modulation in inflammatory disease states may play a role in pathogenesis [16].
Gene_expression (modulation) of LXR associated with inflammation and disease
6) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 1.06 Pain Relevance 0.41
Moreover, the observed effect of T0901317 on iNOS expression is in agreement with a previous study in which Yasuda and colleagues have clearly described that another synthetic LXR agonist, 22R-HC inhibits NO production and iNOS expression in LPS-activated RAW264.7 macrophages suggesting that 22R-HC can negatively regulate excess NO during an inflammatory response, even after the onset of inflammation [31].
Gene_expression (synthetic) of LXR in macrophages associated with inflammatory response, inflammation and agonist
7) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.59 Pain Relevance 0.30
Furthermore, recently it has been demonstrated the expression of LXR in alveolar macrophages, alveolar type II cells, and PMNs and proceed to show potent anti-inflammatory and ant host defense effects of synthetic LXR agonists in the lung [10].
Gene_expression (expression) of LXR in lung associated with inflammation and agonist
8) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.64 Pain Relevance 0.28
agonists have been shown to upregulate LXR and ABCA1 expression and promote macrophage cholesterol efflux (Schmitz et al 2002; Chawla et al 2001).
Gene_expression (expression) of LXR in macrophage associated with agonist
9) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.93 Pain Relevance 0.10
Nuclear regulation of RCT: LXR and PPAR agonists
Gene_expression (agonists) of LXR associated with agonist
10) Confidence 0.31 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.62 Pain Relevance 0.16
Emerging therapies such as Apo AI mimetics (Eriksson et al 1999) and LXR agonists (Plosch et al 2002) increase fecal sterol excretion (FSE), while CETP inhibition with torcetrapib fails to affect fecal sterol content (Brousseau et al 2005).
Gene_expression (mimetics) of LXR associated with agonist
11) Confidence 0.31 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.17 Pain Relevance 0.10
Similarly, treating LDLr KO mice with the LXR ligand, T-0901317, reduced atherosclerotic lesion development without affecting plasma total cholesterol levels (Terasaka et al 2003).
Gene_expression (ligand) of LXR in plasma associated with targeted disruption, atherosclerosis and disorder of lipid metabolism
12) Confidence 0.31 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.79 Pain Relevance 0.32
Gene expression of LXR (p < 0.001) and GR (p < 0.01) in BAL cells of smokers (Figure 2) was up to three times that of nonsmokers, whereas expression of the cytosolic AHR and PXR was similar.
Gene_expression (expression) of LXR associated with nicotine addiction
13) Confidence 0.26 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.66 Pain Relevance 0
Furthermore, recent observations from our laboratory seem to indicate that LXR agonists could exert anti-inflammatory properties antagonizing JNK activation by TNF-?
Gene_expression (agonists) of LXR associated with inflammation and agonist
14) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.60 Pain Relevance 0.32
Another interesting TF was the liver X-activated receptors (LXR) found upstream of several transcripts bearing USF sequence.
Gene_expression (found) of LXR in liver
15) Confidence 0.22 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.80 Pain Relevance 0.15
Another interesting TF was the liver X-activated receptors (LXR) found upstream of several transcripts bearing USF sequence.
Gene_expression (was) of LXR in liver
16) Confidence 0.22 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.80 Pain Relevance 0.15
Another interesting TF was the liver X-activated receptors (LXR) found upstream of several transcripts bearing USF sequence.
Gene_expression (interesting) of LXR in liver
17) Confidence 0.22 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.81 Pain Relevance 0.15
We therefore studied expression of the aryl hydrocarbon receptor (AHR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), liver X receptor (LXR), and glucocorticoid receptor (GR) (Gibson et al. 2002; Tirona et al. 2003) for their established role in CYP gene regulation in BAL cells and BBs derived from smokers and nonsmokers.
Gene_expression (expression) of LXR in CAR associated with nicotine addiction
18) Confidence 0.20 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.57 Pain Relevance 0
The expression of AHR, LXR, PXR and GR was not different in BBs of both study groups.
Gene_expression (expression) of LXR
19) Confidence 0.20 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.58 Pain Relevance 0
The epidermis is a very active site of lipid metabolism, and all peroxisome proliferator-activated receptor (PPAR) and liver X receptor (LXR) isoforms are expressed in the epidermis.
Gene_expression (expressed) of LXR in liver
20) Confidence 0.16 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.44 Pain Relevance 0.37

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