INT176211

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2004
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 24
Disease Relevance 6.04
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcg8) ATPase activity (Abcg8)
Anatomy Link Frequency
livers 3
bile 2
plasma 1
Abcg8 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 1032 98.80 Very High Very High Very High
agonist 72 65.92 Quite High
anesthesia 48 5.00 Very Low Very Low Very Low
isoflurane 24 5.00 Very Low Very Low Very Low
Arthritis 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 912 99.40 Very High Very High Very High
Disease 144 98.00 Very High Very High Very High
Disorder Of Lipid Metabolism 120 78.12 Quite High
Body Weight 72 57.76 Quite High
Coronary Artery Disease 24 22.16 Low Low
Stroke 72 5.00 Very Low Very Low Very Low
Sprains And Strains 24 5.00 Very Low Very Low Very Low
Arthritis 24 5.00 Very Low Very Low Very Low
Lipidosis 24 5.00 Very Low Very Low Very Low
Dislocations 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A mouse model disrupting both Abcg5 and Abcg8 simultaneously results in a phenotype similar to that of the human disease [20].
Negative_regulation (disrupting) of Abcg8 associated with disease
1) Confidence 0.59 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.42 Pain Relevance 0
Does the loss of Abcg8/sterolin-2 result in loss of Abcg5/sterolin-1 expression, as might be predicted from the genetic studies and more recently from the in vitro and in vivo expression studies?
Negative_regulation (loss) of Abcg8
2) Confidence 0.59 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.39 Pain Relevance 0
To investigate the effects of a deficiency of Abcg8/sterolin-2 on the genes that regulate sterol metabolism, quantitative RT-PCR was performed looking at the expression levels of Abcg5, Abcg8, Hmgr, Cyp7a1, Abca1, Mdr2, Lxr, Srebp-1c, and Srebp-2 mRNA in the livers of mice fed a regular chow diet (Figure 4a).
Spec (investigate) Negative_regulation (deficiency) of Abcg8 in livers
3) Confidence 0.59 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.21 Pain Relevance 0
The major findings in this study are: (1) disruption of only one of the two genes comprising the STSL locus is necessary and sufficient to cause sitosterolemia, (2) that the loss of Abcg8/sterolin-2 leads to the loss of biliary cholesterol secretion and (3) Abcg5/sterolin-1 appears to be still apically-expressed despite the absence of Abcg8/sterolin-2.
Negative_regulation (loss) of Abcg8
4) Confidence 0.59 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0 Pain Relevance 0.13
The major findings in this study are: (1) disruption of only one of the two genes comprising the STSL locus is necessary and sufficient to cause sitosterolemia, (2) that the loss of Abcg8/sterolin-2 leads to the loss of biliary cholesterol secretion and (3) Abcg5/sterolin-1 appears to be still apically-expressed despite the absence of Abcg8/sterolin-2.
Negative_regulation (loss) of sterolin
5) Confidence 0.59 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0 Pain Relevance 0.13
Does the loss of Abcg8/sterolin-2 result in loss of Abcg5/sterolin-1 expression, as might be predicted from the genetic studies and more recently from the in vitro and in vivo expression studies?
Negative_regulation (loss) of sterolin
6) Confidence 0.59 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.39 Pain Relevance 0
To investigate the effects of a deficiency of Abcg8/sterolin-2 on the genes that regulate sterol metabolism, quantitative RT-PCR was performed looking at the expression levels of Abcg5, Abcg8, Hmgr, Cyp7a1, Abca1, Mdr2, Lxr, Srebp-1c, and Srebp-2 mRNA in the livers of mice fed a regular chow diet (Figure 4a).
Spec (investigate) Negative_regulation (deficiency) of sterolin in livers
7) Confidence 0.59 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.21 Pain Relevance 0
Furthermore, complete loss of Abcg8/sterolin-2 results in an inability to secrete cholesterol into bile, although secretion of sitosterol seemed to be preserved.
Negative_regulation (loss) of Abcg8 in bile associated with bile
8) Confidence 0.59 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.22 Pain Relevance 0.28
As expected, Abcg8 mRNA expression levels were undetectable in the Abcg8-/- mice and were reduced by ~50% in the heterozygous mice, relative to wild-type mice.
Negative_regulation (reduced) of Abcg8
9) Confidence 0.59 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.28 Pain Relevance 0
To investigate the effects of a deficiency of Abcg8/sterolin-2 on the genes that regulate sterol metabolism, quantitative RT-PCR was performed looking at the expression levels of Abcg5, Abcg8, Hmgr, Cyp7a1, Abca1, Mdr2, Lxr, Srebp-1c, and Srebp-2 mRNA in the livers of mice fed a regular chow diet (Figure 4a).
Spec (investigate) Negative_regulation (deficiency) of Abcg8 in livers
10) Confidence 0.43 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.27 Pain Relevance 0
Mice deficient in Abcg8 have significantly increased plasma and tissue plant sterol levels (sitosterol and campesterol) consistent with sitosterolemia.
Negative_regulation (deficient) of Abcg8 in plasma
11) Confidence 0.43 Published 2004 Journal BMC Med Section Abstract Doc Link PMC394351 Disease Relevance 0.28 Pain Relevance 0.04
These data indicate that Abcg8/sterolin-2 is necessary for biliary sterol secretion and that loss of Abcg8/sterolin-2 has a more profound effect upon biliary cholesterol secretion than sitosterol.
Negative_regulation (loss) of Abcg8
12) Confidence 0.43 Published 2004 Journal BMC Med Section Abstract Doc Link PMC394351 Disease Relevance 0.19 Pain Relevance 0.04
Loss of Abcg8/sterolin-2 does not seem to affect this pattern of staining.
Negative_regulation (Loss) of Abcg8
13) Confidence 0.43 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.12 Pain Relevance 0.03
Furthermore, complete loss of Abcg8/sterolin-2 results in an inability to secrete cholesterol into bile, although secretion of sitosterol seemed to be preserved.
Negative_regulation (loss) of sterolin in bile associated with bile
14) Confidence 0.43 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.22 Pain Relevance 0.28
These data indicate that Abcg8/sterolin-2 is necessary for biliary sterol secretion and that loss of Abcg8/sterolin-2 has a more profound effect upon biliary cholesterol secretion than sitosterol.
Negative_regulation (loss) of sterolin
15) Confidence 0.43 Published 2004 Journal BMC Med Section Abstract Doc Link PMC394351 Disease Relevance 0.19 Pain Relevance 0.04
Mice homozygous for Abcg8 loss exhibit many of the characteristics of the human disease sitosterolemia.
Negative_regulation (loss) of Abcg8 associated with disease
16) Confidence 0.43 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.38 Pain Relevance 0.04
We hypothesized that disruption of only one of the half-transporters would result in sitosterolemia and selective loss of either sterolin may show a differential effect on the biliary secretion of sterols or intestinal absorption of sterols.
Negative_regulation (loss) of sterolin
17) Confidence 0.43 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.44 Pain Relevance 0.03
Loss of Abcg8/sterolin-2 does not seem to affect this pattern of staining.
Negative_regulation (Loss) of sterolin
18) Confidence 0.43 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.12 Pain Relevance 0.03
Does the loss of Abcg8/sterolin-2 result in loss of Abcg5/sterolin-1 expression, as might be predicted from the genetic studies and more recently from the in vitro and in vivo expression studies?
Negative_regulation (loss) of sterolin
19) Confidence 0.43 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.39 Pain Relevance 0
The major findings in this study are: (1) disruption of only one of the two genes comprising the STSL locus is necessary and sufficient to cause sitosterolemia, (2) that the loss of Abcg8/sterolin-2 leads to the loss of biliary cholesterol secretion and (3) Abcg5/sterolin-1 appears to be still apically-expressed despite the absence of Abcg8/sterolin-2.
Negative_regulation (loss) of sterolin
20) Confidence 0.43 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0 Pain Relevance 0.13

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