INT176212

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.92
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1h2) DNA binding (Nr1h2) cytoplasm (Nr1h2)
Anatomy Link Frequency
livers 1
somatotroph 1
bile 1
Nr1h2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 52 96.92 Very High Very High Very High
Inflammatory stimuli 1 69.28 Quite High
Inflammation 46 51.80 Quite High
agonist 16 43.92 Quite Low
anesthesia 6 34.24 Quite Low
dexamethasone 1 31.20 Quite Low
cINOD 1 11.72 Low Low
Kinase C 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
interstitial cystitis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 2 96.52 Very High Very High Very High
Gallstones 2 95.88 Very High Very High Very High
Cancer 29 95.28 Very High Very High Very High
Freckles 10 94.96 High High
Hutchinson-gilford Progeria Syndrome 82 94.76 High High
Cockayne Syndrome 20 92.72 High High
Overactive Bladder 61 75.28 Quite High
Targeted Disruption 48 74.16 Quite High
Disease 22 70.24 Quite High
INFLAMMATION 52 68.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LXR-inducible murine hepatic SULT2A gene transcription has been described and has been shown to confer a protective effect against bile acid toxicity during cholestasis [136].
Transcription (transcription) of LXR-inducible in bile associated with toxicity, bile and gallstones
1) Confidence 0.29 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.25 Pain Relevance 0.09
Several TREs upstream of actg 2 and my19 were over-represented in MIDI, including LXR which was described above, SRF, COUP, Pax-9, CP2, and RFX1.
Transcription (described) of LXR
2) Confidence 0.23 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.43 Pain Relevance 0.06
To investigate the effects of a deficiency of Abcg8/sterolin-2 on the genes that regulate sterol metabolism, quantitative RT-PCR was performed looking at the expression levels of Abcg5, Abcg8, Hmgr, Cyp7a1, Abca1, Mdr2, Lxr, Srebp-1c, and Srebp-2 mRNA in the livers of mice fed a regular chow diet (Figure 4a).
Transcription (levels) of Lxr in livers
3) Confidence 0.16 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.27 Pain Relevance 0
The XPD gene, encoding a helicase subunit of the transcription/NER-associated transcription factor II H complex, is unique amongst NER genes in that different point mutations are associated with cancer (XP), progeria (TTD), or a combination (XP combined with Cockayne syndrome [XPCS] or trichothiodystrophy [XPTTD]) [8,14,15].
Transcription (transcription) of NER-associated associated with cancer, hutchinson-gilford progeria syndrome, cockayne syndrome and freckles
4) Confidence 0.14 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 1.65 Pain Relevance 0
Within this signature group of five somatotroph axis genes, mRNA expression levels were significantly different not only between NER progeroid animals and controls, but also between XPCS/XPA and CH/XPA animals; in each case, downregulation was more severe in XPCS/XPA animals.
Transcription (expression) of NER in somatotroph
5) Confidence 0.09 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.33 Pain Relevance 0

General Comments

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