INT176224

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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.52
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN1A, PCNA) cytoplasm (CDKN1A, PCNA) nucleus (CDKN1A, PCNA)
DNA binding (PCNA) cell proliferation (PCNA) cytosol (CDKN1A)
CDKN1A (Homo sapiens)
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 9 66.96 Quite High
cerebral cortex 27 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 232 100.00 Very High Very High Very High
Stress 9 88.16 High High
Cancer 60 87.32 High High
Neurodegenerative Disease 24 82.08 Quite High
Suicidal Behaviour 81 50.00 Quite Low
Repression 7 43.76 Quite Low
Aging 5 32.68 Quite Low
Death 53 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low
Breast Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Network interaction analysis of the target genes conceived four gene clusters - CDK4, TFAP2A, CDKN1A-p21 and ING1 linked by p53 and PCNA.
p21 Binding (linked) of PCNA
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958829 Disease Relevance 0.98 Pain Relevance 0
For example, PCNA and p21/Waf-1 bind to each other to prevent apoptosis induction [51], and to promote repair of double strand breaks in DNA, a characteristic of apoptosis.
Waf-1 Binding (bind) of PCNA associated with apoptosis
2) Confidence 0.04 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.53 Pain Relevance 0.03
Since p21/Waf-1 may prevent apoptosis by interacting with PCNA [51], we examined the expression of p21/Waf-1 in dissociated embryonic cortical cells that were exposed to sFasL, estrogen or both sFasL and estrogen for 12 hours.
Waf-1 Binding (interacting) of PCNA associated with apoptosis
3) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.50 Pain Relevance 0
Since p21/Waf-1 may prevent apoptosis by interacting with PCNA [51], we examined the expression of p21/Waf-1 in dissociated embryonic cortical cells that were exposed to sFasL, estrogen or both sFasL and estrogen for 12 hours.
p21 Binding (interacting) of PCNA associated with apoptosis
4) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.50 Pain Relevance 0

General Comments

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