INT176224

Context Info Confidence 0.08 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.52 Pain Relevance 0.03

nucleoplasm (CDKN1A, PCNA) cytoplasm (CDKN1A, PCNA) nucleus (CDKN1A, PCNA) DNA binding (PCNA) cell proliferation (PCNA) cytosol (CDKN1A)

CDKN1A (Homo sapiens) PCNA (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 9 66.96 cerebral cortex 27 5.00 metalloproteinase 12 5.00 ischemia 6 5.00 Pain 3 5.00 alcohol 3 5.00 Multiple sclerosis 3 5.00 Hippocampus 3 5.00 Inflammation 2 5.00 cytokine 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 232 100.00 Stress 9 88.16 Cancer 60 87.32 Neurodegenerative Disease 24 82.08 Suicidal Behaviour 81 50.00 Repression 7 43.76 Aging 5 32.68 Death 53 5.00 Adhesions 12 5.00 Breast Cancer 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Network interaction analysis of the target genes conceived four gene clusters - CDK4, TFAP2A, CDKN1A-p21 and ING1 linked by p53 and PCNA.

p21 Binding (linked) of PCNA

1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958829 Disease Relevance 0.98 Pain Relevance 0

For example, PCNA and p21/Waf-1 bind to each other to prevent apoptosis induction [51], and to promote repair of double strand breaks in DNA, a characteristic of apoptosis.

Waf-1 Binding (bind) of PCNA associated with apoptosis

2) Confidence 0.04 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.53 Pain Relevance 0.03

Since p21/Waf-1 may prevent apoptosis by interacting with PCNA [51], we examined the expression of p21/Waf-1 in dissociated embryonic cortical cells that were exposed to sFasL, estrogen or both sFasL and estrogen for 12 hours.

Waf-1 Binding (interacting) of PCNA associated with apoptosis

3) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.50 Pain Relevance 0

Since p21/Waf-1 may prevent apoptosis by interacting with PCNA [51], we examined the expression of p21/Waf-1 in dissociated embryonic cortical cells that were exposed to sFasL, estrogen or both sFasL and estrogen for 12 hours.

p21 Binding (interacting) of PCNA associated with apoptosis

4) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.50 Pain Relevance 0

General Comments

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