INT176238

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.94
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cdk1) protein complex assembly (Cdk1) cytoplasm (Cdk1)
mitosis (Cdk1) nucleus (Cdk1) cell cycle (Cdk1)
Cdk1 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 21 71.04 Quite High
agonist 9 29.48 Quite Low
cINOD 8 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 102 84.60 Quite High
Targeted Disruption 82 82.56 Quite High
Neurodegenerative Disease 12 78.64 Quite High
Death 35 73.92 Quite High
Apoptosis 118 71.60 Quite High
Stress 13 71.12 Quite High
Repression 10 67.44 Quite High
Suicidal Behaviour 27 62.40 Quite High
Cancer 56 57.68 Quite High
Infection 10 28.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upstream signaling pathways involved in the blockage of G2/M transition included lack of persistent Erk1/2 activation and inability to up-regulate the levels of Cdk1, Plk1, Aurora A and B, and Mad2 along with a defective histone 3 phosphorylation and lack of chromatin condensation.
Gene_expression (levels) of Cdk1
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.13 Pain Relevance 0
Cdk1 and MAPK assay
Gene_expression (assay) of Cdk1
2) Confidence 0.43 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.08 Pain Relevance 0.04
Meanwhile, mutant Htt expression did not suppress activities of other kinases such as Cdk1/Cdc2 or MAPK/extracellular-regulated kinase (ERK; Fig. 5 F), supporting the view that the effect of mutant Htt on DNA–PK could be specific to some extent.
Gene_expression (/) of Cdk1
3) Confidence 0.43 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.05 Pain Relevance 0
However, the expressions of various genes involved in cell cycle regulation

(PCNA, c-myc, CDK1, CDK4, and

Gene_expression (expressions) of CDK1
4) Confidence 0.28 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.38 Pain Relevance 0
Similarly, neither estrogen nor sFasL significantly altered the expression of Cyclin-dependent Kinase-1 (cdk1/cdc2) relative to control cultures, suggesting that that interactions between estrogen and Fas activation were not specifically related to cell cycle.


Gene_expression (expression) of cdk1
5) Confidence 0.14 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.29 Pain Relevance 0

General Comments

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