INT176241

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.16
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp6v1e1) endosome (Atp6v1e1) transport (Atp6v1e1)
mitochondrion (Atp6v1e1) cytoplasm (Atp6v1e1)
Anatomy Link Frequency
ovaries 4
neuron 2
Atp6v1e1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 96.40 Very High Very High Very High
Neuropeptide 5 93.72 High High
antagonist 3 27.92 Quite Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 81 99.80 Very High Very High Very High
Sprains And Strains 94 97.12 Very High Very High Very High
Apoptosis 77 77.96 Quite High
Targeted Disruption 17 54.04 Quite High
Salivary Gland Disease 8 50.04 Quite High
Suicidal Behaviour 27 50.00 Quite Low
Cancer 44 5.00 Very Low Very Low Very Low
Systemic Lupus Erythematosus 30 5.00 Very Low Very Low Very Low
Death 17 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All animals were well owed to recover for two weeks and then received daily s. c. injections of either E2 (100 µg/kg/day) or CpG (1.2 mg/Kg/day) only or both which were dissolved in sesame oil or PBS every morning for 2 weeks.
Negative_regulation (received) of Gene_expression (injections) of E2
1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0.10
In functional tests of hpg kisspeptin neuron responsiveness, the distribution of kisspeptin immunoreactivity in the OVX+E2-treated hpg ARC was restored to the pattern found in WT mice.
Negative_regulation (treated) of Gene_expression (distribution) of E2 in neuron associated with aids-related complex
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.64 Pain Relevance 0.08
Because nude mice lack functional ovaries and consequently have very low E2 levels, this hormone had to be supplemented (20 ?
Negative_regulation (low) of Gene_expression (levels) of E2 in ovaries
3) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.63 Pain Relevance 0
Because nude mice lack functional ovaries and consequently have very low E2 levels, this hormone had to be supplemented (20 ?
Negative_regulation (have) of Gene_expression (levels) of E2 in ovaries
4) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.68 Pain Relevance 0
Twenty-four hours of exposure to 2 nM E2 led to a statistically significant, 1.5-fold decrease in the percentage of cells in G0/G1 that expressed Fas (Figure 7A:E2 and 7B).
Negative_regulation (decrease) of Gene_expression (expressed) of E2
5) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.21 Pain Relevance 0

General Comments

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