INT176243

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
smooth muscle cells 4
neuronal 2
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 7 26.96 Quite Low
cerebral cortex 18 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 281 100.00 Very High Very High Very High
Stress 32 97.76 Very High Very High Very High
Aging 7 96.80 Very High Very High Very High
Repression 4 86.56 High High
Disease 131 86.40 High High
Toxicity 15 80.00 Quite High
Diabetes Mellitus 1 68.24 Quite High
Increased Venous Pressure Under Development 1 61.56 Quite High
Suicidal Behaviour 54 50.00 Quite Low
Hyperlipidemia 1 49.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, repressor functions have been ascribed to estrogen receptors acting at the promoters for IGF-1 and IGF-1 receptor in aortic smooth muscle cells [83] and specific residues on ER?
Positive_regulation (ascribed) of IGF-1 Binding (receptor) of in smooth muscle cells
1) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.15 Pain Relevance 0
Furthermore, repressor functions have been ascribed to estrogen receptors acting at the promoters for IGF-1 and IGF-1 receptor in aortic smooth muscle cells [83] and specific residues on ER?
Positive_regulation (ascribed) of IGF-1 Binding (receptor) of in smooth muscle cells
2) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.15 Pain Relevance 0
Thus, it is conceivable that a decline in metabolic and hormonal function in aging, together with accumulation of oxidative stress, can influence neuronal vulnerability to other concomitant insults and result in neuronal degeneration through activation of apoptotic cascades.

5.5 IGF-1, Wnt signaling and GSK-3?

Positive_regulation (activation) of IGF-1 Binding (5.5) of in neuronal associated with stress, aging and apoptosis
3) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.07 Pain Relevance 0

General Comments

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