INT176250

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Context Info
Confidence 0.13
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pcna) intracellular (Pcna) DNA binding (Pcna)
transcription factor binding (Pcna) cytoplasm (Pcna)
Anatomy Link Frequency
neuroblasts 1
BxPC-3 1
Pcna (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 11 50.00 Quite Low
Inflammation 11 29.52 Quite Low
alcohol 4 10.88 Low Low
ischemia 11 7.60 Low Low
cerebral cortex 36 5.00 Very Low Very Low Very Low
metalloproteinase 16 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Peripheral nerve injury 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 60 94.00 High High
Apoptosis 360 92.08 High High
Adhesions 17 89.76 High High
Suicidal Behaviour 108 85.64 High High
Death 100 82.96 Quite High
Malignant Neoplastic Disease 6 82.12 Quite High
Nervous System Injury 9 73.84 Quite High
Pancreatic Cancer 30 50.00 Quite Low
Dna Damage 2 32.48 Quite Low
INFLAMMATION 11 29.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclins and the cyclin dependent kinases (CDKs) play a central role in regulating the cell cycle progression in all eukaryotic organisms [2].
Positive_regulation (dependent) of cyclin
1) Confidence 0.13 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.16 Pain Relevance 0
p21/Waf1 = Wild-type p53-activated fragment 1 or cyclin-dependent kinase inhibitor 1A
Positive_regulation (activated) of cyclin
2) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.33 Pain Relevance 0
It is likely therefore, that the induction of cyclin-A increases activation of associated kinases, even though CDK2 levels were not altered, leading to feedback activation of the estrogen receptor, further suppression of Fas expression, and neuro-protection.
Positive_regulation (induction) of cyclin
3) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.61 Pain Relevance 0
The latter hypothesis is supported by our observation that estrogen and Fas-ligand both separately and together, significantly increased Cyclin-A.
Positive_regulation (increased) of Cyclin
4) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.70 Pain Relevance 0
Cyclin-A is a G1/S-phase cyclin, so it is not surprising that estrogen would up-regulate this cyclin as a consequence of increasing the number of neuroblasts that enter S-phase.
Positive_regulation (increasing) of cyclin in neuroblasts
5) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.69 Pain Relevance 0
More recent study, however, has altered this view and revealed that even p21cip1 proteins are specific inhibitors of Cyclin E- and A-dependent Cdk2, they act as positive regulators of Cyclin D-dependent kinases.31 Thus, the increase of Cyclin D1 level in BxPC-3 cells may be the consequence of the overexpression of p21cip1.
Positive_regulation (regulators) of Cyclin in BxPC-3
6) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.11 Pain Relevance 0
Based on in vitro and in vivo studies, the Cip/Kip family including p21Cip1 were initially thought to interfere with the activation of G1/S phase related Cyclin/Cdk complexes.
Positive_regulation (activation) of Cyclin
7) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.91 Pain Relevance 0

General Comments

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