INT176266

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 99.44 Very High Very High Very High
cytokine 4 94.84 High High
Inflammation 2 44.28 Quite Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 8 76.56 Quite High
Apoptosis 76 70.56 Quite High
Stress 9 61.80 Quite High
Suicidal Behaviour 27 50.00 Quite Low
INFLAMMATION 2 44.28 Quite Low
Death 18 5.00 Very Low Very Low Very Low
Shock 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly (see discussion), concurrent exposure to the estrogenic antagonist 4-hydroxytamoxifen did not prevent the estrogen-induced reduction in Fas.


Negative_regulation (prevent) of Negative_regulation (reduction) of Fas associated with antagonist
1) Confidence 0.22 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.27 Pain Relevance 0.09
Hence there was an up-regulation of pathways such as nfkb, rela, tnfr2 and tob1 while there was a down-regulation of FAS.
Negative_regulation (down) of Negative_regulation (regulation) of FAS
2) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.06 Pain Relevance 0.08

General Comments

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