INT176269

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 4.30
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
extracellular matrix 1
p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 10 88.96 High High
alcohol 10 81.76 Quite High
ischemia 20 78.48 Quite High
antagonist 30 76.40 Quite High
cerebral cortex 90 72.00 Quite High
Pain 10 33.52 Quite Low
Multiple sclerosis 10 28.36 Quite Low
metalloproteinase 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 740 98.42 Very High Very High Very High
Suicidal Behaviour 270 96.32 Very High Very High Very High
Aging 10 95.20 Very High Very High Very High
Genomic Instability 10 94.52 High High
Death 170 92.72 High High
Convulsion 10 89.32 High High
Cancer 40 87.56 High High
Neurodegenerative Disease 80 85.52 High High
Fetal Alcohol Syndrome 10 82.24 Quite High
Cv General 4 Under Development 10 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since Fas expression was positively associated with p53 phosphorylation, it is likely that estrogen protection against apoptosis is contextual, i.e., dependent on the activation of p53.
Phosphorylation (phosphorylation) of p53 associated with apoptosis
1) Confidence 0.12 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.36 Pain Relevance 0.04
We had previously observed that estrogen prevented apoptosis in T-antigen-synchronized cultures, following p53 activation (as indicated by p53 phosphorylation at serine 392, and activation of prototypic p53-responsive genes like MDM2, p21/Waf-1 and Bax) [37].
Phosphorylation (phosphorylation) of p53 associated with apoptosis
2) Confidence 0.12 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.35 Pain Relevance 0.03
For example, we found that estrogen promotes p53 phosphorylation [37], but uncouples p53 from its regulation of Bax, a mitochondrial-associated pro-apoptotic factor.
Phosphorylation (phosphorylation) of p53 associated with apoptosis
3) Confidence 0.12 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.73 Pain Relevance 0.08
Thus, cells that exhibit high levels of p53 phosphorylation also express high cell-surface levels of Fas.
Phosphorylation (phosphorylation) of p53
4) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.21 Pain Relevance 0
Our observation of a positive relationship between the activation of p53 (p53 phosphorylation) and Fas expression is particularly germane to the issue of cell cycle control, since p53 regulates progression through cell-cycle checkpoints [55,56].
Phosphorylation (phosphorylation) of p53
5) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.49 Pain Relevance 0
Developmentally, cell-surface Fas expression is modulated by a variety of competing factors including cell-cycle stage, extracellular matrix interactions, p53 phosphorylation and hormone availability.
Phosphorylation (phosphorylation) of p53 in extracellular matrix
6) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.85 Pain Relevance 0.08
For example, we found that estrogen promotes p53 phosphorylation [37], but uncouples p53 from its regulation of Bax, a mitochondrial-associated pro-apoptotic factor.
Phosphorylation (phosphorylation) of p53 associated with apoptosis
7) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.73 Pain Relevance 0.08
We used phosphorylation of p53 at serine 392 as a marker for p53 activation [37].
Phosphorylation (phosphorylation) of p53
8) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.33 Pain Relevance 0
Subsequently, FLIP or phosphorylated P53 was detected using rabbit polyclonal anti-FLIP (gift from Drs.
Phosphorylation (phosphorylated) of P53
9) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0 Pain Relevance 0
However, cessation of large T antigen expression (-tsTA, 39°C) is accompanied by induction of the p53 phosphorylation and the induction of p53-dependent proteins, p21/Waf1, Bax and MDM2 that lead to cell cycle-arrest, suicide, and p53 inhibition/cell cycle re-entry respectively.
Phosphorylation (phosphorylation) of p53 associated with suicidal behaviour
10) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.24 Pain Relevance 0

General Comments

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