INT176270

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
embryos 1
p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 2 94.60 High High
antagonist 3 93.72 High High
cerebral cortex 9 17.08 Low Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gestational Diabetes 9 99.82 Very High Very High Very High
Apoptosis 84 83.80 Quite High
Diabetes Mellitus 50 81.84 Quite High
Congenital Anomalies 8 62.84 Quite High
Repression 2 51.36 Quite High
Suicidal Behaviour 27 50.00 Quite Low
Fetal Diseases 2 44.84 Quite Low
Death 17 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maternal diabetes did not alter embryonic p53 (as noted previously [43]) and PARP expression in the present study, despite a putative PARP activity increase due to the presence of DNA damage in the MD embryos (29).
Neg (not) Regulation (alter) of p53 in embryos associated with gestational diabetes
1) Confidence 0.30 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.45 Pain Relevance 0.05
We previously observed a similar tamoxifen-independent effect of estrogen on the regulation of p53 itself [37], suggesting that estrogen may regulate cell-surface Fas expression by non-classical mechanisms including transcriptional activation mediated by AP-1 [78] or activation of protein kinase pathways [79,80].
Regulation (regulation) of p53
2) Confidence 0.04 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.34 Pain Relevance 0.05

General Comments

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