INT176271

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Context Info
Confidence 0.06
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 2
p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 213 96.48 Very High Very High Very High
nMDA receptor 2 88.12 High High
ischemia 133 70.32 Quite High
Inflammation 7 66.12 Quite High
Inflammatory mediators 1 64.68 Quite High
Inflammatory response 1 61.84 Quite High
cytokine 5 36.48 Quite Low
isoflurane 4 30.20 Quite Low
Kinase C 15 5.00 Very Low Very Low Very Low
cerebral cortex 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 80 100.00 Very High Very High Very High
Neurodegenerative Disease 9 99.28 Very High Very High Very High
Suicidal Behaviour 27 92.88 High High
Cv Unclassified Under Development 122 70.32 Quite High
INFLAMMATION 9 66.12 Quite High
Injury 12 50.96 Quite High
Necrosis 2 33.92 Quite Low
Cancer 6 33.56 Quite Low
Death 22 5.00 Very Low Very Low Very Low
Hypoxia 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogen prevents apoptosis following p53 activation and induces both neurogenesis and neuronal differentiation in this cell line.
Negative_regulation (prevents) of Positive_regulation (activation) of p53 in neuronal associated with neurodegenerative disease and apoptosis
1) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.29 Pain Relevance 0
Anti-apoptotic mechanisms induced by PC are several: induction of Bcl-2, reductions in caspase-3 synthesis and p-53 activation, and reductions in mitochondrial cytochrome c [9,185].


Negative_regulation (reductions) of Positive_regulation (activation) of p-53 associated with apoptosis
2) Confidence 0.01 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.86 Pain Relevance 0.54

General Comments

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