INT176272

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.96
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 5 89.32 High High
antagonist 15 76.40 Quite High
cerebral cortex 45 70.08 Quite High
Multiple sclerosis 5 28.72 Quite Low
ischemia 10 27.92 Quite Low
metalloproteinase 20 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 370 98.48 Very High Very High Very High
Suicidal Behaviour 135 95.96 Very High Very High Very High
Convulsion 5 89.68 High High
Cancer 20 87.92 High High
Death 85 76.28 Quite High
Reprotox - General 1 5 75.72 Quite High
Neurodegenerative Disease 40 72.24 Quite High
Injury 5 58.48 Quite High
Disease 10 29.56 Quite Low
Demyelinating Disease 5 28.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, we found that estrogen promotes p53 phosphorylation [37], but uncouples p53 from its regulation of Bax, a mitochondrial-associated pro-apoptotic factor.
Positive_regulation (promotes) of Phosphorylation (phosphorylation) of p53 associated with apoptosis
1) Confidence 0.10 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.74 Pain Relevance 0.08
We had previously observed that estrogen prevented apoptosis in T-antigen-synchronized cultures, following p53 activation (as indicated by p53 phosphorylation at serine 392, and activation of prototypic p53-responsive genes like MDM2, p21/Waf-1 and Bax) [37].
Positive_regulation (activation) of Phosphorylation (phosphorylation) of p53 associated with apoptosis
2) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.40 Pain Relevance 0.03
However, cessation of large T antigen expression (-tsTA, 39°C) is accompanied by induction of the p53 phosphorylation and the induction of p53-dependent proteins, p21/Waf1, Bax and MDM2 that lead to cell cycle-arrest, suicide, and p53 inhibition/cell cycle re-entry respectively.
Positive_regulation (induction) of Phosphorylation (phosphorylation) of p53 associated with suicidal behaviour
3) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.24 Pain Relevance 0
Thus, cells that exhibit high levels of p53 phosphorylation also express high cell-surface levels of Fas.
Positive_regulation (levels) of Phosphorylation (phosphorylation) of p53
4) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.21 Pain Relevance 0
Since Fas expression was positively associated with p53 phosphorylation, it is likely that estrogen protection against apoptosis is contextual, i.e., dependent on the activation of p53.
Positive_regulation (associated) of Phosphorylation (phosphorylation) of p53 associated with apoptosis
5) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.36 Pain Relevance 0.04

General Comments

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