INT176273

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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.98
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 13.48 Low Low
cerebral cortex 18 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 148 99.52 Very High Very High Very High
Suicidal Behaviour 54 90.24 High High
Repression 4 73.08 Quite High
Death 34 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 16 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogen's anti-apoptotic role may be to prevent the initiation of apoptosis in the first place, by suppressing expression of p53-activated proteins like Fas (as reported above) and Bax [37] or alternatively, antagonizing p53 more directly.
Negative_regulation (suppressing) of Gene_expression (expression) of p53 associated with apoptosis
1) Confidence 0.08 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.85 Pain Relevance 0
While our data indicates that estrogen suppresses the expression of p53-induced proteins like Bax [37] and Fas, other data indicates that p53 can suppress estrogen receptor activation [85], by preventing ER-alpha binding to EREs.
Negative_regulation (suppresses) of Gene_expression (expression) of p53
2) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.12 Pain Relevance 0

General Comments

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