INT176281

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.71
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
intermediary 1
p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 4 87.76 High High
cerebral cortex 36 72.00 Quite High
Multiple sclerosis 4 27.16 Quite Low
ischemia 8 26.36 Quite Low
metalloproteinase 16 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 296 99.52 Very High Very High Very High
Suicidal Behaviour 108 88.32 High High
Convulsion 4 88.12 High High
Cancer 16 86.36 High High
Reprotox - General 1 4 74.16 Quite High
Death 68 68.24 Quite High
Injury 4 56.92 Quite High
Disease 8 28.00 Quite Low
Demyelinating Disease 4 27.16 Quite Low
Cv Unclassified Under Development 4 26.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, we found that estrogen promotes p53 phosphorylation [37], but uncouples p53 from its regulation of Bax, a mitochondrial-associated pro-apoptotic factor.
p53 Binding (uncouples) of associated with apoptosis
1) Confidence 0.05 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.72 Pain Relevance 0.08
However, cyclin-A can also antagonize p53-dependent apoptosis [50] by preventing the association between p53 and E2F, and therefore, may represent the preferred intermediary for estrogen suppression of apoptosis.
p53 Binding (association) of in intermediary associated with apoptosis
2) Confidence 0.05 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.67 Pain Relevance 0
Phosphorylation at this site promotes tetramerization of p53 [90] and specificity of p53 binding to DNA [91], while regulating re-annealing of double-stranded DNA [92].
p53 Binding (binding) of
3) Confidence 0.05 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0 Pain Relevance 0
Fas expression in embryonic cortical-derived precursors is associated with p53 activation
p53 Binding (associated) of
4) Confidence 0.05 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.32 Pain Relevance 0

General Comments

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