INT176290

Context Info Confidence 0.02 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.44 Pain Relevance 0

intracellular (Pcna) DNA binding (Pcna) cytoplasm (Pcna) extracellular space (Fasl) signal transduction (Fasl) extracellular region (Fasl)

Anatomy Link Frequency neuronal precursors 1 Fasl (Mus musculus) Pcna (Mus musculus)

Pain Link Frequency Relevance Heat alcohol 1 34.96 ischemia 2 31.68 cerebral cortex 9 5.00 metalloproteinase 4 5.00 antagonist 3 5.00 Pain 1 5.00 Multiple sclerosis 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 74 99.78 Suicidal Behaviour 27 94.04 Neurodegenerative Disease 8 38.72 Fetal Alcohol Syndrome 1 35.44 Cv General 4 Under Development 1 32.40 Hydrocephalus 1 28.48 Brain Injury 1 26.16 Disease 2 23.68 Death 17 5.00 Adhesions 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

If cyclin-A represents a means for limiting apoptosis, then the induction of cyclin A by sFasL, suggests that neuronal precursors may initiate adaptive anti-apoptotic mechanisms (aside from FLIP expression), in response to the activation of a suicide receptor.

sFasL Positive_regulation (induction) of cyclin in neuronal precursors associated with suicidal behaviour and apoptosis

1) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.44 Pain Relevance 0

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