INT1763

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Context Info
Confidence 0.36
First Reported 1979
Last Reported 2010
Negated 8
Speculated 9
Reported most in Body
Documents 43
Total Number 56
Disease Relevance 23.98
Pain Relevance 10.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
fibroblasts 8
PGE2 6
chondrocytes 4
cartilage 4
endothelial cell 4
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 730 100.00 Very High Very High Very High
Osteoarthritis 552 100.00 Very High Very High Very High
COX2 63 100.00 Very High Very High Very High
Pain 36 99.88 Very High Very High Very High
Analgesic 14 99.24 Very High Very High Very High
Potency 12 99.12 Very High Very High Very High
dexamethasone 8 99.12 Very High Very High Very High
COX-2 inhibitor 130 97.88 Very High Very High Very High
Infliximab 40 94.56 High High
rheumatoid arthritis 41 94.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 900 100.00 Very High Very High Very High
Osteoarthritis 563 100.00 Very High Very High Very High
Adhesions 87 100.00 Very High Very High Very High
Herpes Simplex Virus 476 99.98 Very High Very High Very High
Pain 40 99.88 Very High Very High Very High
Pulmonary Sarcoidosis 1 98.68 Very High Very High Very High
Colorectal Cancer 73 98.64 Very High Very High Very High
Uveitis 1 98.18 Very High Very High Very High
Colon Cancer 203 97.04 Very High Very High Very High
Stomach Cancer 13 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mutations may both affect PGE2 production per se via a regulation of COX enzymes in pro-inflammatory cells including epithelial cells as well as the PGE2-dependent signaling pathways in target cells, Figure 1.
Spec (may) Regulation (affect) of Gene_expression (production) of PGE2 in PGE2 associated with inflammation
1) Confidence 0.36 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 1.17 Pain Relevance 0.27
Since high levels of prostaglandin (PG) E2 and interleukin (IL)-1 beta are found in the periodontal ligament (PDL) during tooth movement, and both factors are involved in the induction of pain, the effects of low-power laser irradiation on PGE2 and IL-1 beta production in stretched human PDL cells were studied in vitro.
Regulation (effects) of Gene_expression (production) of PGE2 in PDL associated with pain
2) Confidence 0.29 Published 1995 Journal J. Dent. Res. Section Abstract Doc Link 7560389 Disease Relevance 0.36 Pain Relevance 0.36
These mutations may both affect PGE2 production per se via a regulation of COX enzymes in pro-inflammatory cells including epithelial cells as well as the PGE2-dependent signaling pathways in target cells, Figure 1.
Spec (may) Regulation (affect) of Gene_expression (production) of PGE2 in PGE2 associated with inflammation
3) Confidence 0.26 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 1.17 Pain Relevance 0.27
Intriguingly, changes in cAMP levels in response to particular PGE2 doses inversely correlate with their proliferative potency (compare Figs. 1A and 3A): Thus, mitogenic PGE2 doses either down regulate or do not ostensibly affect cAMP levels whereas anti or non-proliferative PGE2 concentrations do in all cases elevate cAMP.
Neg (not) Regulation (regulate) of Gene_expression (doses) of PGE2 associated with potency
4) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.24 Pain Relevance 0.05
Since endogenous production of PGE2 might significantly affect the outcome of the proliferation assays, in particular in those points treated with low concentrations of exogenous PGE2, we used a COX inhibitor to negate any possible contribution of auto/paracrine effects.
Spec (might) Regulation (affect) of Gene_expression (production) of PGE2
5) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.15 Pain Relevance 0.04
Intriguingly, changes in cAMP levels in response to particular PGE2 doses inversely correlate with their proliferative potency (compare Figs. 1A and 3A): Thus, mitogenic PGE2 doses either down regulate or do not ostensibly affect cAMP levels whereas anti or non-proliferative PGE2 concentrations do in all cases elevate cAMP.
Neg (not) Regulation (affect) of Gene_expression (doses) of PGE2 associated with potency
6) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.24 Pain Relevance 0.05
These in vitro experiments suggest that the pathogenesis of rheumatoid inflammation involves interactions between monocyte-macrophages, lymphocytes, and synovial cells regulating the production of PGE2, cAMP, and other factors.
Regulation (regulating) of Gene_expression (production) of PGE2 in lymphocytes associated with inflammation
7) Confidence 0.13 Published 1979 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 231404 Disease Relevance 0.23 Pain Relevance 0.17
Epidermal keratinocytes (used as a positive control for PGE2 production) were isolated from one healthy Caucasian individual (Table 1) and cultured in keratinocyte–serum free medium (supplemented as described previously).
Regulation (control) of Gene_expression (production) of PGE2 in keratinocyte
8) Confidence 0.07 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.09 Pain Relevance 0
However, it would seem that for some EM donors COX-2 may have little involvement in PGE2 production.
Neg (little) Regulation (involvement) of Gene_expression (production) of PGE2
9) Confidence 0.07 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0 Pain Relevance 0.04
However, PGE2 production was unaffected by colchicine whereas retinoic acid caused a significant increase in PGE2 levels.
Neg (unaffected) Regulation (unaffected) of Gene_expression (production) of PGE2
10) Confidence 0.07 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.16 Pain Relevance 0.36
Dexamethasone, colchicine or retinoic acid all inhibited collagenase synthesis by monocytes in a dose-dependent manner although the effect of these drugs on monocyte PGE2 synthesis differed.
Regulation (effect) of Gene_expression (synthesis) of PGE2 in monocytes associated with dexamethasone
11) Confidence 0.07 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.16 Pain Relevance 0.36
B) in leptin-stimulated NO, PGE2, IL-6, and IL-8 production in OA cartilage was studied by pharmacological means.
Regulation (studied) of Gene_expression (production) of PGE2 in cartilage associated with osteoarthritis
12) Confidence 0.06 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.38 Pain Relevance 0.23
BW helped to generate the hypothesis regarding the role of COX2 and PGE2 synthesis and to perform the respective experiments.
Regulation (role) of Gene_expression (synthesis) of PGE2 associated with cox2
13) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0 Pain Relevance 0.18
The potential role of Nuc in the regulation of PGE2 production is of interest in a large number of physiological settings, and the present report might be a first step in a characterization of this pivotal enzymatic complex.


Regulation (regulation) of Gene_expression (production) of PGE2
14) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373884 Disease Relevance 0 Pain Relevance 0.03
By contrast, there was no correlation between PGE2 production by EM and their melanogenic status.
Neg (no) Regulation (correlation) of Gene_expression (production) of PGE2 in PGE2
15) Confidence 0.05 Published 2010 Journal Pigment Cell & Melanoma Research Section Abstract Doc Link PMC2881306 Disease Relevance 0.13 Pain Relevance 0.08
The level of PGE2 synthesis remained unchanged in cells from four other individuals (37, 42, 48 and 50) (Figure 4A).
Neg (unchanged) Regulation (unchanged) of Gene_expression (synthesis) of PGE2
16) Confidence 0.05 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.15 Pain Relevance 0.04
In order to further investigate the involvement of the two COX isoforms in PGE2 production in EM, indomethacin (a non-selective COX inhibitor) and NS-398 (a selective COX-2 inhibitor) were employed.
Spec (investigate) Regulation (involvement) of Gene_expression (production) of PGE2 associated with cox-2 inhibitor
17) Confidence 0.05 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0 Pain Relevance 0.05
In order to investigate the effect of skin phototype of EM donor on PGE2 production in response to UVB, data for all SPT-1 and SPT-4 EM cultures were pooled separately (Figure 4B).
Spec (investigate) Regulation (effect) of Spec (investigate) Gene_expression (production) of PGE2 in skin
18) Confidence 0.05 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.18 Pain Relevance 0.06
Indomethacin (IM) enhanced TNF production in all the eight TCC that were established from a patient with human T lymphotrophic virus type 1 uveitis or pulmonary sarcoidosis, and suppressed IL-6 production in six of the eight TCC, without affecting their low levels of PGE2 production.
Neg (without) Regulation (affecting) of Gene_expression (production) of PGE2 associated with pulmonary sarcoidosis and uveitis
19) Confidence 0.05 Published 1995 Journal Cytokine Section Abstract Doc Link 8589268 Disease Relevance 0.34 Pain Relevance 0.51
PGE2 is reported to have anabolic effects on cartilage: increasing proteoglycan and collagen synthesis [41], stimulating proliferation and aggrecan synthesis [42], up-regulating glucocorticoid receptors [43] and, at low concentrations, stimulating collagen II synthesis.
Regulation (regulating) of Gene_expression (synthesis) of PGE2 in cartilage
20) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246251 Disease Relevance 0.28 Pain Relevance 0.03

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