INT176351

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.82
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (POU2F1) nucleus (POU2F1)
Anatomy Link Frequency
leukocyte 2
joint 1
POU2F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 120 99.44 Very High Very High Very High
Inflammation 57 96.38 Very High Very High Very High
tolerance 3 94.24 High High
cytokine 12 91.84 High High
Osteoarthritis 6 83.24 Quite High
Arthritis 18 78.08 Quite High
antagonist 3 72.88 Quite High
Inflammatory response 12 5.00 Very Low Very Low Very Low
methotrexate 9 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 132 99.84 Very High Very High Very High
Chronic Disease 3 99.04 Very High Very High Very High
Anaemia 3 98.66 Very High Very High Very High
Disease 156 98.28 Very High Very High Very High
Arthritis 15 96.38 Very High Very High Very High
Adhesions 9 95.60 Very High Very High Very High
Apoptosis 12 93.84 High High
INFLAMMATION 69 91.66 High High
Osteoarthritis 6 83.24 Quite High
Autoimmune Disease 24 70.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the genes for YKL-40 (or cartilage protein-39), a cartilage-derived autoantigen that is up-regulated in RA and thought to be a direct target of autoimmune attack in that disease [40-43], EDG-1, a pro-angiogenic protein essential for vascular maturation [44], and Oct-1, a transcription factor expressed in RA synovial cells and which regulates gene transcription [21], were more highly variable in JRA than in controls, indicating that these proteins may play a major role in joint-specific pathology, including erosions, in polyarticular JRA, although they were not detected as significantly differentially regulated.
Gene_expression (expressed) of Oct-1 in joint associated with rheumatoid arthritis and disease
1) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400410 Disease Relevance 1.24 Pain Relevance 0.24
, another potent anti-inflammatory cytokine, which is involved in many biologic processes including immune homeostasis, regulation of apoptosis, and self-tolerance [21]; IL-8, which has been shown to be elevated in JRA patients and plays a key role in joint inflammation by recruiting neutrophils to synovial tissue and fluid [22,23]; ferritin, highlighting the significance of anemia of chronic disease associated with JRA [24]; transcription factor octamer-binding protein (Oct-1), which is expressed in synovial cells in the majority of RA patients and may modulate synovial outgrowth [25]; CD63, a leukocyte adhesion molecule and marker of dendritic cell maturation and neutrophil activation [26-28]; and GLUT/SLC2A, a glucose transporter protein expressed by chondrocytes that is regulated by TNF-?
Gene_expression (expressed) of octamer-binding protein in leukocyte associated with rheumatoid arthritis, apoptosis, cytokine, inflammation, anaemia, tolerance, adhesions, arthritis and chronic disease
2) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400410 Disease Relevance 1.29 Pain Relevance 0.55
, another potent anti-inflammatory cytokine, which is involved in many biologic processes including immune homeostasis, regulation of apoptosis, and self-tolerance [21]; IL-8, which has been shown to be elevated in JRA patients and plays a key role in joint inflammation by recruiting neutrophils to synovial tissue and fluid [22,23]; ferritin, highlighting the significance of anemia of chronic disease associated with JRA [24]; transcription factor octamer-binding protein (Oct-1), which is expressed in synovial cells in the majority of RA patients and may modulate synovial outgrowth [25]; CD63, a leukocyte adhesion molecule and marker of dendritic cell maturation and neutrophil activation [26-28]; and GLUT/SLC2A, a glucose transporter protein expressed by chondrocytes that is regulated by TNF-?
Gene_expression (expressed) of Oct-1 in leukocyte associated with rheumatoid arthritis, apoptosis, cytokine, inflammation, anaemia, tolerance, adhesions, arthritis and chronic disease
3) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400410 Disease Relevance 1.28 Pain Relevance 0.54

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