INT176356

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.28
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (POU2F1) nucleus (POU2F1)
Anatomy Link Frequency
joint 1
POU2F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 40 94.80 High High
Osteoarthritis 2 88.40 High High
Inflammation 19 62.80 Quite High
Arthritis 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 52 100.00 Very High Very High Very High
Rheumatoid Arthritis 44 99.44 Very High Very High Very High
Osteoarthritis 2 88.40 High High
Autoimmune Disease 8 65.64 Quite High
INFLAMMATION 23 62.80 Quite High
Stress 1 8.04 Low Low
Arthritis 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Juvenile Chronic Polyarthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the genes for YKL-40 (or cartilage protein-39), a cartilage-derived autoantigen that is up-regulated in RA and thought to be a direct target of autoimmune attack in that disease [40-43], EDG-1, a pro-angiogenic protein essential for vascular maturation [44], and Oct-1, a transcription factor expressed in RA synovial cells and which regulates gene transcription [21], were more highly variable in JRA than in controls, indicating that these proteins may play a major role in joint-specific pathology, including erosions, in polyarticular JRA, although they were not detected as significantly differentially regulated.
Regulation (target) of Oct-1 in joint associated with rheumatoid arthritis and disease
1) Confidence 0.15 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400410 Disease Relevance 1.28 Pain Relevance 0.24

General Comments

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