INT176368

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2004
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.53
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
synovium 2
IL18 (Homo sapiens)
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 297 100.00 Very High Very High Very High
cytokine 51 98.96 Very High Very High Very High
Inflammation 15 39.04 Quite Low
methotrexate 12 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 297 100.00 Very High Very High Very High
Disease 18 78.68 Quite High
Aging 6 55.20 Quite High
INFLAMMATION 18 39.04 Quite Low
Adhesions 12 5.00 Very Low Very Low Very Low
Mycobacterial Infection 12 5.00 Very Low Very Low Very Low
Opportunistic Infections 3 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00 Very Low Very Low Very Low
Autoimmune Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite this stimulation, IL-18 by itself did not induce either H- or RA-PBMCs to produce IFN-?.
IL-18 Neg (not) Positive_regulation (induce) of Gene_expression (produce) of IFN associated with rheumatoid arthritis
1) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.87 Pain Relevance 0.44
IL-18 stimulates the synthesis of IFN-?
IL-18 Positive_regulation (stimulates) of Gene_expression (synthesis) of IFN
2) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.36 Pain Relevance 0.34
IL-12 alone but not IL-18 induced total RA synovium cells to produce significant amounts of IFN-?.
IL-18 Neg (not) Positive_regulation (induced) of Gene_expression (produce) of IFN in synovium associated with rheumatoid arthritis
3) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.29 Pain Relevance 0.57

General Comments

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