INT176386

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 9.17
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
macrophages 4
T cells 4
joints 2
poly 2
keratinocytes 2
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 250 100.00 Very High Very High Very High
Inflammation 175 99.80 Very High Very High Very High
Arthritis 99 99.56 Very High Very High Very High
rheumatoid arthritis 162 99.12 Very High Very High Very High
chemokine 29 99.12 Very High Very High Very High
Inflammatory response 19 97.16 Very High Very High Very High
tolerance 20 94.24 High High
psoriasis 54 90.40 High High
methotrexate 5 78.32 Quite High
abatacept 1 72.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 198 99.80 Very High Very High Very High
Experimental Arthritis 2 99.56 Very High Very High Very High
Recurrence 34 99.42 Very High Very High Very High
Rheumatoid Arthritis 237 99.12 Very High Very High Very High
Cancer 13 98.22 Very High Very High Very High
Disease Progression 3 96.20 Very High Very High Very High
Infection 130 96.04 Very High Very High Very High
Mycobacterial Infection 27 94.40 High High
Disease 177 94.04 High High
Synovitis 14 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ratio between Th1 and Th2 response was calculated as ratio between concentrations of Th1 cytokines (IL-12 + IFN-?)
Positive_regulation (Ratio) of Gene_expression (response) of Th1 associated with cytokine
1) Confidence 0.32 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.19 Pain Relevance 0.15
It is now clear that some experimental arthritis models are dependent on Th1/IFN?
Positive_regulation (on) of Gene_expression (/) of Th1 associated with experimental arthritis and arthritis
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 1.37 Pain Relevance 0.20
The expression of the classic Th1-associated cytokines IFN?
Positive_regulation (cytokines) of Gene_expression (expression) of Th1-associated associated with cytokine
3) Confidence 0.28 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.27 Pain Relevance 0.58
It is of interest that clinical benefit was restricted to those patients who showed a marked increase in the levels of Th1 cytokine producing T cells in their circulation immediately after administration of the mAb [47].
Positive_regulation (increase) of Gene_expression (producing) of Th1 in T cells associated with cytokine
4) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.84 Pain Relevance 0.38
Thus, RA patients have a polarized immune response, Th1 being overexpressed in inflamed joints and Th1 defects in peripheral circulation.


Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Th1 in joints associated with rheumatoid arthritis
5) Confidence 0.26 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.33 Pain Relevance 0.47
Because of the naturally delayed production of TH1 mediated pro-inflammatory cytokines (i.e.
Positive_regulation (mediated) of Gene_expression (production) of TH1 associated with inflammation and cytokine
6) Confidence 0.23 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.90 Pain Relevance 0.26
A clinically effective therapeutic vaccine to fight viruses or tumour requires the generation and expansion of specific cytotoxic T lymphocytes (CTL) able to proliferate and/or secrete Th1-type cytokines such as IL-2, IFN?
Positive_regulation (proliferate) of Gene_expression (cytokines) of Th1-type in cytotoxic T lymphocytes associated with cancer and cytokine
7) Confidence 0.23 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.16 Pain Relevance 0.11
Patients who suffered relapse, showed neither significant elevation of Th1 cytokines nor downregulation of IL-10, at this time point, although TGF-?
Neg (neither) Positive_regulation (elevation) of Gene_expression (cytokines) of Th1 associated with recurrence and cytokine
8) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.57 Pain Relevance 0.22
This phenotype is characterized by high capacity to present antigens and high capacity to produce IL-12 (promoting Th1 responses) and IL-23 (promoting maturation and survival of IL-17 producing T cells), as well as microbicidal nitric oxide and reactive oxygen intermediates.
Positive_regulation (promoting) of Gene_expression (responses) of Th1 in T cells
9) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.48 Pain Relevance 0.21
We could indeed show that Th2 cytokines do not induce hBD-2 expression in cultured keratinocytes [18] and that Th2 cytokines repress the Th1 induced expression (not shown here), as was previously shown for hBD-3 [43].
Neg (not) Positive_regulation (induced) of Gene_expression (expression) of Th1 in keratinocytes associated with cytokine
10) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.11 Pain Relevance 0.54
Using HPV16 capsomeres at low doses (10 µg/animal) as a relevant viral antigen with low immunogenicity, we also showed that poly ICLC, but not CpG-C (which supported the induction of humoral responses, however), supports the induction of HPV16-specific Th1 responses.
Positive_regulation (induction) of Gene_expression (responses) of Th1 in poly
11) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.08 Pain Relevance 0
responsiveness in L. donovani-infected macrophages; in the same model, miltefosine induced an IL-12-dependent Th1 response and reversed the Th2 response to Th1 response [49].
Positive_regulation (induced) of Gene_expression (response) of Th1 in macrophages
12) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.25 Pain Relevance 0.04
An essential component of cell-mediated immunity against Leishmania is the development of a Th1 type response that activates macrophages via IFN-?
Positive_regulation (mediated) of Gene_expression (response) of Th1 in macrophages
13) Confidence 0.08 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710502 Disease Relevance 0.39 Pain Relevance 0.08
Due to immune restoration, an inflammatory response against infectious and non-infectious antigens (LPS) is mounted leading to noticeable 'paradoxical worsening' [43-45], with a shift toward a Th1 receptor profile, which increases the levels of IFN-?
Positive_regulation (increases) of Gene_expression (profile) of Th1 receptor associated with inflammatory response
14) Confidence 0.05 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.24 Pain Relevance 0.16

General Comments

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