INT176400

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.63
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.


Pain Term Frequency Confidence Heat
Hippocampus 29 98.72 Very High Very High Very High
Arthritis 1 78.12 Quite High
Osteoarthritis 6 76.12 Quite High
metalloproteinase 72 50.00 Quite Low
depression 3 45.84 Quite Low
cerebral cortex 6 40.96 Quite Low
alcohol 1 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Stress 219 97.84 Very High Very High Very High
Apoptosis 75 96.16 Very High Very High Very High
Hypoxia 31 93.28 High High
Death 148 89.96 High High
Targeted Disruption 47 87.76 High High
Alzheimer's Dementia 13 80.40 Quite High
Disease 71 79.24 Quite High
Arthritis 10 78.12 Quite High
Osteoarthritis 6 76.12 Quite High
Manic Depressive Disorder 19 65.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein expression and phosphorylation state of the eukaryotic translation initiation factor 2 alpha (eIF2?)
Gene_expression (expression) of eIF2
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004931 Disease Relevance 0.32 Pain Relevance 0
The fraction of phosphorylated eIF2?
Gene_expression (fraction) of eIF2
2) Confidence 0.65 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.49 Pain Relevance 0
(to total eIF2?)
Gene_expression (total) of eIF2
3) Confidence 0.65 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.48 Pain Relevance 0
To determine whether PERK signaling is involved in WFS1 upregulation by valproate, we measured expression levels of phosphorylated eIF2?
Gene_expression (expression) of eIF2
4) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.72 Pain Relevance 0
Boyce et al. [18] reported that selective inhibition of eIF2?
Gene_expression (selective) of eIF2
5) Confidence 0.65 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.88 Pain Relevance 0
levels without affecting total eIF2?
Gene_expression (affecting) of eIF2
6) Confidence 0.65 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.61 Pain Relevance 0.12
increases PACT protein expression and phosphorylation of PKR and eIF2?
Gene_expression (expression) of eIF2
7) Confidence 0.58 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400415 Disease Relevance 1.14 Pain Relevance 0.08

General Comments

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