INT17641

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 33
Total Number 33
Disease Relevance 8.85
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP1) nucleus (NLRP1) intracellular (NLRP1)
enzyme binding (NLRP1) cytoplasm (NLRP1)
Anatomy Link Frequency
Caco-2 3
urine 2
embryo 1
plasma 1
atlas 1
NLRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nucleus accumbens 75 100.00 Very High Very High Very High
gABA 10 100.00 Very High Very High Very High
Opioid 4 99.98 Very High Very High Very High
Ventral tegmentum 52 99.96 Very High Very High Very High
cytokine 178 99.36 Very High Very High Very High
Dopamine 147 99.20 Very High Very High Very High
antagonist 15 98.96 Very High Very High Very High
Gabapentin 10 98.50 Very High Very High Very High
cocaine 15 98.48 Very High Very High Very High
narcan 2 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 112 98.84 Very High Very High Very High
Sepsis 206 98.80 Very High Very High Very High
Allergic Dermatitis 6 96.68 Very High Very High Very High
Fever 17 96.00 Very High Very High Very High
Depression 18 95.32 Very High Very High Very High
Headache 7 95.32 Very High Very High Very High
Respiratory Distress 6 94.92 High High
Lung Injury 12 94.16 High High
Hemorrhage 6 94.04 High High
Pressure Volume 2 Under Development 6 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of this Nalp1 form that might be a processed form of the 160 kDa protein or a yet to be described isoform that lacks all leucine rich repeats (LRRs) has been found to be present in K562, Jurkat, and THP-1 cells as well as T-lymphocytes and dendritic cells [15].
Gene_expression (expression) of Nalp1 in THP-1
1) Confidence 0.73 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.07 Pain Relevance 0
Similarly, in the nucleus accumbens (NAc) and lateral septal nucleus (LSN), the majority of clozapine-induced FLI neurons express D3 receptor mRNA (NAc 69%; LS 73%).
Gene_expression (express) of NAc in septal nucleus associated with nucleus accumbens
2) Confidence 0.58 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9629567 Disease Relevance 0 Pain Relevance 1.26
The relative expression of Nalp1, the sensory component of Nalp1 inflammasome, was comparable in the immortalized and primary cells.
Gene_expression (expression) of Nalp1
3) Confidence 0.57 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.05
However, we could not detect the expression of Nalp3 protein while we detected the expression of a shorter isoform of Nalp1.
Gene_expression (expression) of Nalp1
4) Confidence 0.57 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.07 Pain Relevance 0
The relative expression of Nalp1, the sensory component of Nalp1 inflammasome, was comparable in the immortalized and primary cells.
Gene_expression (expression) of Nalp1
5) Confidence 0.57 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.05
However, NAC was only minimally detectable in plasma of two fetal animals and transiently reached quantifiable levels in two others.
Gene_expression (detectable) of NAC in plasma
6) Confidence 0.50 Published 1991 Journal Ann Emerg Med Section Body Doc Link 1928876 Disease Relevance 0 Pain Relevance 0
A standard dose of NAC stimulates urinary excretion of MeHg with a relatively constant predictive ratio
Gene_expression (dose) of NAC
7) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0 Pain Relevance 0
The injection of NAC was followed by a sharp increase in urinary MeHg excretion at all MeHg doses (Figure 3A).
Gene_expression (injection) of NAC
8) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0 Pain Relevance 0
By administering 1 mmol NAC/kg to male and female rats exposed to 0.1 ?
Gene_expression (/) of NAC
9) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0.06 Pain Relevance 0
The experiment was terminated 2.5 hr after NAC injection.
Gene_expression (injection) of NAC
10) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0 Pain Relevance 0
The total percentage excreted in the 2 hr after NAC injection was not different between sexes when a single dose was given, but this became significant when two doses of NAC were given within the same time period, with the male group being slightly higher (Figure 1B).
Gene_expression (injection) of NAC
11) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0.07 Pain Relevance 0
Control animals excreted only minimal amounts of MeHg in urine (< 0.1% in 2 hr following vehicle injection), but this was markedly enhanced by increasing doses of NAC (Figure 2 A,B).
Gene_expression (increasing) of NAC in urine
12) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0 Pain Relevance 0
Fresh NAC solution was prepared daily.
Gene_expression (solution) of NAC
13) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0 Pain Relevance 0
After oral NAC administration, NAC is rapidly absorbed from the gastrointestinal tract, and blood NAC levels rise quickly (Borgstrom et al. 1986; Rodenstein et al. 1978).
Gene_expression (administration) of NAC in blood
14) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0 Pain Relevance 0
To test the hypothesis that a standardized dose of NAC will produce an increase in urinary MeHg excretion that is proportional to the body burden of MeHg, we treated animals with different doses of MeHg (0.01–1.0 ?
Gene_expression (dose) of NAC in body
15) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0 Pain Relevance 0
NAC was previously shown to be protective against MeHg-induced embryo-toxicity (Ornaghi et al. 1993), although the mechanism was not identified.
Gene_expression (protective) of NAC in embryo associated with toxicity
16) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0.18 Pain Relevance 0
Except for the lowest MeHg dose, the percentage excreted in the 2 hr following NAC injection was relatively constant, with a mean ± SD of 5.2 ± 0.3% of dose excreted over this time period (Figure 3B).
Gene_expression (injection) of NAC
17) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0.06 Pain Relevance 0
It is important to note that NAC itself is also efficiently cleared by the kidney and excreted into urine in high concentrations (Borgstrom et al. 1986; Rodenstein et al. 1978).
Gene_expression (cleared) of NAC in urine
18) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0 Pain Relevance 0.03
Opioid transmission in the NAc is associated with dopamine release in the VTA.
Gene_expression (transmission) of NAc in NAc associated with ventral tegmentum, nucleus accumbens, dopamine and opioid
19) Confidence 0.39 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19914781 Disease Relevance 0.48 Pain Relevance 1.03
We found that NAC infusion (150 mg/kg intravenous bolus, followed by intravenous infusion at 12.5 mg/kg per hour for 6 hours) did not affect cytokine levels, patient outcomes, or pHi in severe sepsis in humans.
Gene_expression (infusion) of NAC associated with sepsis and cytokine
20) Confidence 0.27 Published 2004 Journal Crit Care Section Body Doc Link PMC522835 Disease Relevance 1.31 Pain Relevance 0.27

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox