INT176453

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 28.27
Pain Relevance 12.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joint 3
endothelial cell 1
cartilage 1
dendritic cells 1
knee 1
Cia1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 1748 100.00 Very High Very High Very High
Inflammation 566 100.00 Very High Very High Very High
agonist 108 99.84 Very High Very High Very High
rheumatoid arthritis 981 99.80 Very High Very High Very High
Acupuncture 57 99.74 Very High Very High Very High
tolerance 19 99.16 Very High Very High Very High
cytokine 394 94.88 High High
chemokine 101 94.12 High High
Inflammatory response 58 82.88 Quite High
Multiple sclerosis 53 77.64 Quite High
Disease Link Frequency Relevance Heat
Arthritis 1677 100.00 Very High Very High Very High
INFLAMMATION 593 100.00 Very High Very High Very High
Disease 428 100.00 Very High Very High Very High
Experimental Arthritis 160 100.00 Very High Very High Very High
Autoimmune Disease 148 100.00 Very High Very High Very High
Rheumatoid Arthritis 992 99.80 Very High Very High Very High
Pressure And Volume Under Development 180 99.76 Very High Very High Very High
Adhesions 21 99.42 Very High Very High Very High
Disease Progression 34 93.52 High High
Hypersensitivity 97 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results demonstrated that development of CIA was associated with increased IDO activity and enhanced tryptophan catabolism in mice.
Negative_regulation (development) of CIA associated with arthritis
1) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206348 Disease Relevance 0.99 Pain Relevance 0.42
Our analyses in E/P-selectin mutant mice suggested that these adhesion molecules may influence the development of CIA by altering the production of MIP-1?
Negative_regulation (development) of CIA associated with adhesions and arthritis
2) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.95 Pain Relevance 0.51
We also demonstrated that agonist B7-H4Ig is a potent inhibitor of CIA progression.
Negative_regulation (inhibitor) of CIA associated with agonist and arthritis
3) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.15 Pain Relevance 0.50
Suppression of CIA by Agonist B7-H4
Negative_regulation (Suppression) of CIA associated with agonist and arthritis
4) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.77 Pain Relevance 0.46
Consistent with previously published observations from different laboratories, our observation thus supports a critical role of B7-H4 in the inhibition of adaptive immunity, leading to suppression of autoimmune diseases in the CIA model.
Negative_regulation (suppression) of CIA associated with autoimmune disease and arthritis
5) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.20 Pain Relevance 0.42
These results suggest that EA at ST36 may suppress autoimmunity in CIA (Fig. 3).
Spec (may) Negative_regulation (suppress) of CIA associated with autoimmune disease, acupuncture and arthritis
6) Confidence 0.08 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810363 Disease Relevance 1.84 Pain Relevance 0.94
In addition, the decreased tissue GSH levels (Figure 4(b)) and catalase activities (Figure 4(c)) in vehicle-treated CIA mice were rescued by oral administration of LE or rLE.
Negative_regulation (decreased) of CIA associated with arthritis
7) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2841253 Disease Relevance 1.55 Pain Relevance 0.69
The pathological events apparent in vehicle-treated CIA mice were substantially reduced in the joints of LE- and rLE-treated CIA mice (Figure 2(b)).
Negative_regulation (reduced) of CIA in joints associated with arthritis
8) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2841253 Disease Relevance 1.83 Pain Relevance 0.73
The mice were observed at least twice a week for development of CIA.
Negative_regulation (development) of CIA associated with arthritis
9) Confidence 0.05 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400434 Disease Relevance 0.78 Pain Relevance 0.16
This might be reflected by the different pattern of paw and knee swelling: while paw thickness in the CIA model steadily increases during the whole observation period, the knee swelling in AIA has a maximum at day 1 and decreases thereafter.
Negative_regulation (thickness) of CIA in knee associated with pressure and volume under development and arthritis
10) Confidence 0.05 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.30 Pain Relevance 0.47
The marked reduction of CIA in mice, the changes in synovial tissue from mice with CIA after IFN-?
Negative_regulation (reduction) of CIA associated with arthritis
11) Confidence 0.04 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416442 Disease Relevance 1.17 Pain Relevance 0.56
blockade has been shown to be effective in both CIA and RA [34-36].
Negative_regulation (effective) of CIA associated with rheumatoid arthritis and arthritis
12) Confidence 0.04 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416442 Disease Relevance 1.06 Pain Relevance 0.42
In addition, suppression of CIA was observed using antibodies against TNF?
Negative_regulation (suppression) of CIA associated with arthritis
13) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.02 Pain Relevance 0.47
Charbonnier and colleagues demonstrated that vaccination with immature dendritic cells suppresses CIA in mice and induces tolerance by expansion of an immuno-regulatory TCR?
Negative_regulation (suppresses) of CIA in dendritic cells associated with tolerance and arthritis
14) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.82 Pain Relevance 0.51
CIA is suppressed in IL-17-deficient mice, and administration of neutralising anti-IL17 antibodies significantly reduces the severity of CIA (reviewed in [46]).
Negative_regulation (suppressed) of CIA associated with arthritis
15) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.98 Pain Relevance 0.50
The estrogen-mediated suppression of inflammation and joint destruction in murine CIA is dependent on ER?
Negative_regulation (suppression) of CIA in joint associated with inflammation and arthritis
16) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.94 Pain Relevance 0.25
Therapeutic treatment with EE decreased the serum COMP (biomarker of cartilage destruction) levels in CIA, which is in line with the protective effect of EE on cartilage destruction as measured with histopathology (Figure 4a).
Negative_regulation (decreased) of CIA in cartilage associated with arthritis
17) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.02 Pain Relevance 0.46
Previous studies have reported that established CIA, induced in rats by chick collagen, was significantly reduced by treatment with the MetAP-2 inhibitor AGM-470 [31-33].
Negative_regulation (reduced) of CIA associated with arthritis
18) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246249 Disease Relevance 1.02 Pain Relevance 0.48
We have shown that long-term administration of PPI-2458 reduces chronic relapsing CIA, a model that has previously been shown to mimic human RA, and to abolish endothelial cell angiogenic responses to key mediators, namely VEGF and FGF-2.
Negative_regulation (reduces) of CIA in endothelial cell associated with rheumatoid arthritis and arthritis
19) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246249 Disease Relevance 0.72 Pain Relevance 0.52
We observed that PPI-2458, as well as reducing acute CIA, significantly decreased disease severity and joint destruction in chronic relapsing CIA.
Negative_regulation (decreased) of CIA in joint associated with disease and arthritis
20) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246249 Disease Relevance 1.96 Pain Relevance 0.72

General Comments

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