INT17646

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Context Info
Confidence 0.77
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.75
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (HSPA8) cytosol (HSPA8) plasma membrane (HSPA8)
intracellular (HSPA8) response to stress (HSPA8) cytoplasm (HSPA8)
Anatomy Link Frequency
cardiac muscle cells 2
myocardium 1
endothelial cells 1
HSPA8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 15 98.80 Very High Very High Very High
Inflammation 4 96.88 Very High Very High Very High
Arthritis 1 96.32 Very High Very High Very High
spinal inflammation 1 85.72 High High
rheumatoid arthritis 2 83.96 Quite High
Neuritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 10 100.00 Very High Very High Very High
Bullous Skin Disease 1 99.72 Very High Very High Very High
Stress 50 99.28 Very High Very High Very High
Injury 30 99.12 Very High Very High Very High
Cv General 3 Under Development 9 98.80 Very High Very High Very High
Epidermolysis Bullosa Acquisita 1 98.76 Very High Very High Very High
Coronary Artery Disease 330 98.28 Very High Very High Very High
Lyme Disease 1 98.12 Very High Very High Very High
Inflammatory Bowel Disease 2 97.44 Very High Very High Very High
Seronegative Spondarthritis 1 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, further studies conducted in cardiac tissues, vascular smooth muscle and/or endothelial cells would be necessary to draw conclusions about the possible effects of the rs2236659 SNP on HSPA8 expression.
Gene_expression (expression) of HSPA8 in endothelial cells
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2838785 Disease Relevance 0.31 Pain Relevance 0
In cardiac muscle cells, overexpression of HSPA8 attenuated oxidative injuries and enhanced cell survival[5].
Gene_expression (overexpression) of HSPA8 in cardiac muscle cells associated with injury
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2838785 Disease Relevance 0.89 Pain Relevance 0
Consistent with the computation, our study confirmed that C allele of SNP rs2236659 leads to an increase in promoter activity and probably heightens synthesis level of the corresponding HSPA8 protein which could decreases the risk of CHD.
Gene_expression (synthesis) of HSPA8 associated with coronary artery disease
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2838785 Disease Relevance 0.53 Pain Relevance 0
By using global expression data available from human lymphoblastoid cell lines[23], we did not find any evidence that rs2236659 directly influences HSPA8 expression.
Gene_expression (expression) of HSPA8
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2838785 Disease Relevance 0.38 Pain Relevance 0
Selection of tagSNPs in HSPA8 Gene
Gene_expression (Selection) of HSPA8 Gene
5) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2838785 Disease Relevance 0.31 Pain Relevance 0
Thus both stress-inducible Hsp70 and constitutively expressed HSPA8 can perform some similar functions and are capable of protecting cardiac muscle cells against injuries like an oxidative challenge[5], [6].
Gene_expression (expressed) of HSPA8 in cardiac muscle cells associated with stress and injury
6) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2838785 Disease Relevance 0.81 Pain Relevance 0
Anti-hsp73 autoantibodies were detected in 20% or more of the sera from patients with Lyme disease and ulcerative colitis.
Gene_expression (detected) of hsp73 associated with inflammatory bowel disease and lyme disease
7) Confidence 0.53 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 1930332 Disease Relevance 2.44 Pain Relevance 0.37
We hypothetized that unstable angina influences the myocardium, and investigated the expression of the inducible heat shock protein 72 (HSP72), constitutive HSP73, and endothelial nitric oxide synthase (eNOS), and activation of the transcription factors NFkappaB and AP-1 in cardiac tissue.
Spec (investigated) Gene_expression (expression) of HSP73 in myocardium associated with angina and shock
8) Confidence 0.21 Published 2000 Journal Cardiovasc. Res. Section Abstract Doc Link 10869529 Disease Relevance 0.53 Pain Relevance 0.26
Levels of the constitutively expressed Hsp70 form (Hsc70) do not change after any stimulus.
Gene_expression (expressed) of Hsc70
9) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 0.54 Pain Relevance 0

General Comments

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