INT176468

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Context Info
Confidence 0.52
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.47
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp14) cytoplasm (Mmp14)
Anatomy Link Frequency
endothelial cells 1
fibroblasts 1
Mmp14 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 90 100.00 Very High Very High Very High
rheumatoid arthritis 280 98.36 Very High Very High Very High
Osteoarthritis 19 88.64 High High
Somatostatin 2 43.64 Quite Low
Arthritis 25 42.96 Quite Low
cva 1 34.52 Quite Low
cytokine 48 29.44 Quite Low
Pain 5 20.28 Low Low
Inflammation 68 5.00 Very Low Very Low Very Low
chemokine 56 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 55 99.16 Very High Very High Very High
Fibrosarcoma 2 98.72 Very High Very High Very High
Rheumatoid Arthritis 280 98.36 Very High Very High Very High
Reprotox - General 1 1 98.28 Very High Very High Very High
Skin Cancer 1 96.32 Very High Very High Very High
Disease 41 83.44 Quite High
Malignant Neoplastic Disease 1 83.08 Quite High
Cancer 12 80.16 Quite High
Congenital Anomalies 3 76.96 Quite High
Bone Cancer 1 57.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membrane type 1-MMP mRNA is detected in endothelial cells and fibroblasts of RA synovia, and there is less expression of the protease in control synovia [125].
Transcription (detected) of Membrane type 1-MMP in endothelial cells associated with rheumatoid arthritis and metalloproteinase
1) Confidence 0.52 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.74 Pain Relevance 0.67
Membrane type 1-MMP mRNA is detected in endothelial cells and fibroblasts of RA synovia, and there is less expression of the protease in control synovia [125].
Transcription (detected) of Membrane type 1-MMP in fibroblasts associated with rheumatoid arthritis and metalloproteinase
2) Confidence 0.18 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.74 Pain Relevance 0.67
Clodronate also inhibited the expression of the MT1-MMP protein and mRNA in the HT1080 fibrosarcoma cell line, and decreased the invasion of C8161 melanoma and HT1080 fibrosarcoma cell lines [73].


Transcription (expression) of MT1-MMP associated with fibrosarcoma and skin cancer
3) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.99 Pain Relevance 0.18

General Comments

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