INT176474

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.90
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (CXCL9) cytoplasm (CXCR3) signal transducer activity (CXCR3)
extracellular space (CXCL9) signal transduction (CXCL9) extracellular region (CXCL9)
Anatomy Link Frequency
endothelium 1
CXCR3 (Homo sapiens)
CXCL9 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 116 99.98 Very High Very High Very High
rheumatoid arthritis 183 99.12 Very High Very High Very High
Osteoarthritis 19 63.36 Quite High
cytokine 26 58.52 Quite High
Inflammation 51 40.08 Quite Low
metalloproteinase 13 5.00 Very Low Very Low Very Low
Arthritis 11 5.00 Very Low Very Low Very Low
Infliximab 6 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 183 99.12 Very High Very High Very High
Pulmonary Sarcoidosis 2 97.64 Very High Very High Very High
Sarcoidosis 40 90.44 High High
Systemic Lupus Erythematosus 40 81.24 Quite High
Osteoarthritis 38 77.48 Quite High
Adhesions 28 62.72 Quite High
Autoimmune Disease 3 59.84 Quite High
Hypoxia 3 56.08 Quite High
Apoptosis 5 50.00 Quite Low
Granuloma 1 44.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-inducible chemokines CXCL9 and CXCL10, both ligands for CXCR3, have been found in chronically inflamed synovial tissue [10].
CXCR3 Binding (ligands) of CXCL9 associated with chemokine
1) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.56 Pain Relevance 0.40
Further more, it has been shown that CXCR3 ligands, that is the M1 markers CXCL9, CXCL10 and CXCL11, seem essential in the pathogenesis of pulmonary sarcoidosis [6,7].
CXCR3 Binding (ligands) of CXCL9 associated with pulmonary sarcoidosis
2) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.44 Pain Relevance 0.16
Some recent studies, however, have shown that CXCR3 (the receptor for IP-10 and MIG) is expressed by the RA synovial endothelium, suggesting that this receptor mediates the angiostatic response to these chemokines [59].
CXCR3 Binding (receptor) of MIG in endothelium associated with chemokine and rheumatoid arthritis
3) Confidence 0.04 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.90 Pain Relevance 0.49

General Comments

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