INT176476

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, SELE) plasma membrane (TNF, SELE) signal transduction (TNF)
extracellular region (TNF) cell adhesion (SELE) intracellular (TNF)
Anatomy Link Frequency
endothelial cells 2
TNF (Homo sapiens)
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 17 97.68 Very High Very High Very High
Inflammation 30 86.48 High High
rheumatoid arthritis 121 84.56 Quite High
antagonist 1 75.92 Quite High
Infliximab 5 74.00 Quite High
Etanercept 1 70.48 Quite High
Pain 2 61.20 Quite High
methotrexate 1 47.28 Quite Low
Arthritis 10 46.48 Quite Low
chemokine 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 86.48 High High
Rheumatoid Arthritis 121 84.56 Quite High
Pain 2 61.20 Quite High
Apoptosis 5 50.00 Quite Low
Arthritis 10 46.48 Quite Low
Disease 13 43.76 Quite Low
Adhesions 28 32.08 Quite Low
Osteoarthritis 18 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 9 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, IL-1 and TNF upregulate the expression of ICAM-1, VCAM-1 and E-selectin on endothelial cells, stimulating leukocyte migration into the joint [76,104].
TNF Positive_regulation (upregulate) of Gene_expression (expression) of E-selectin in endothelial cells
1) Confidence 0.04 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.57 Pain Relevance 0.63

General Comments

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