INT176477

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.61
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (CXCL10) cytoplasm (CXCR3) signal transducer activity (CXCR3)
extracellular space (CXCL10) signal transduction (CXCL10) extracellular region (CXCL10)
Anatomy Link Frequency
monocytes 2
fibroblasts 2
eosinophils 2
Th1 cells 1
NK cells 1
CXCR3 (Homo sapiens)
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 529 99.96 Very High Very High Very High
rheumatoid arthritis 223 98.80 Very High Very High Very High
Inflammatory response 1 96.16 Very High Very High Very High
Arthritis 31 91.36 High High
Inflammation 137 90.52 High High
agonist 4 86.04 High High
cytokine 324 83.80 Quite High
antagonist 21 82.92 Quite High
Osteoarthritis 19 63.36 Quite High
Sicca syndrome 2 62.04 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 229 98.80 Very High Very High Very High
Pulmonary Sarcoidosis 2 97.96 Very High Very High Very High
INFLAMMATION 145 96.16 Very High Very High Very High
Infection 157 95.36 Very High Very High Very High
Mycobacterial Infection 4 95.08 Very High Very High Very High
Eye Disease 130 94.20 High High
Pulmonary Disease 4 93.20 High High
Colitis 2 91.72 High High
Arthritis 31 91.36 High High
Sarcoidosis 40 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-inducible chemokines CXCL9 and CXCL10, both ligands for CXCR3, have been found in chronically inflamed synovial tissue [10].
CXCR3 Binding (ligands) of CXCL10 associated with chemokine
1) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.56 Pain Relevance 0.40
Further more, it has been shown that CXCR3 ligands, that is the M1 markers CXCL9, CXCL10 and CXCL11, seem essential in the pathogenesis of pulmonary sarcoidosis [6,7].
CXCR3 Binding (ligands) of CXCL10 associated with pulmonary sarcoidosis
2) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.44 Pain Relevance 0.16
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
CXCR3 Binding (ligand) of IP-10 in monocytes
3) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.58
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
CXCR3 Binding (ligand) of CXCL10 in monocytes
4) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.58
IP-10/CXCL10 is a high-affinity ligand for the CXCR3 chemokine receptor which is mainly expressed on helper T1 (Th1) cells.
CXCR3 Binding (ligand) of IP-10 associated with chemokine
5) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.48 Pain Relevance 0.56
IP-10/CXCL10 is a high-affinity ligand for the CXCR3 chemokine receptor which is mainly expressed on helper T1 (Th1) cells.
CXCR3 Binding (ligand) of CXCL10 associated with chemokine
6) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.48 Pain Relevance 0.56
IP-10 and I-TAC are both ligands for the CXCR3 chemokine receptor and the production of these chemokines leads to the recruitment of CXCR3 expressing T cells and NK cells [31],[32].
CXCR3 Binding (ligands) of IP-10 in NK cells associated with chemokine
7) Confidence 0.06 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 0.83 Pain Relevance 0.26
CXCL10 is known for its activity to attract effector Th1 cells through interaction with its receptor CXCR3 at sites for the expression of Th1 immune responses [68], e.g., rejection of allografts or the inflammatory response upon mycobacterial infection [69],[70].
CXCR3 Binding (interaction) of CXCL10 in Th1 cells associated with mycobacterial infection and inflammatory response
8) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.25 Pain Relevance 0.08
IP-10/ CXCL10 binds to cells through the CXCR3 receptor, which is preferentially expressed in Th1 cells as well as in eosinophils.
CXCR3 receptor Binding (binds) of IP-10 in eosinophils
9) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.90 Pain Relevance 0.40
IP-10/ CXCL10 binds to cells through the CXCR3 receptor, which is preferentially expressed in Th1 cells as well as in eosinophils.
CXCR3 receptor Binding (binds) of CXCL10 in eosinophils
10) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.90 Pain Relevance 0.40
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
CXCR3 Binding (ligand) of IP-10 in fibroblasts
11) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.58
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
CXCR3 Binding (ligand) of CXCL10 in fibroblasts
12) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.58
Some recent studies, however, have shown that CXCR3 (the receptor for IP-10 and MIG) is expressed by the RA synovial endothelium, suggesting that this receptor mediates the angiostatic response to these chemokines [59].
CXCR3 Binding (receptor) of IP-10 in endothelium associated with chemokine and rheumatoid arthritis
13) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.85 Pain Relevance 0.49
IP-10 and I-TAC are both ligands for the CXCR3 chemokine receptor and the production of these chemokines leads to the recruitment of CXCR3 expressing T cells and NK cells [31],[32].
CXCR3 Binding (ligands) of IP-10 in T cells associated with chemokine
14) Confidence 0.02 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 0.83 Pain Relevance 0.26

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