INT176479

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.33
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL17A, TIMP1) extracellular space (IL17A) aging (TIMP1)
cell death (IL17A) cell-cell signaling (IL17A)
Anatomy Link Frequency
leukocyte 2
IL17A (Homo sapiens)
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 121 100.00 Very High Very High Very High
metalloproteinase 13 100.00 Very High Very High Very High
cytokine 17 96.96 Very High Very High Very High
Inflammation 30 77.56 Quite High
methotrexate 1 73.28 Quite High
Pain 2 66.00 Quite High
Infliximab 5 64.28 Quite High
Etanercept 1 61.60 Quite High
antagonist 1 19.88 Low Low
chemokine 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 121 100.00 Very High Very High Very High
Severe Combined Immunodeficiency 1 99.68 Very High Very High Very High
Adhesions 28 86.24 High High
Osteoarthritis 18 83.28 Quite High
INFLAMMATION 27 77.56 Quite High
Arthropathy 1 68.08 Quite High
Pain 2 66.00 Quite High
Apoptosis 5 50.00 Quite Low
Pressure And Volume Under Development 9 12.00 Low Low
Disease 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-17 is produced by the RA synovium, induces production of metalloproteinases and could activate the endothelium enhancing leukocyte extravasation [111].
IL-17 Positive_regulation (induces) of Gene_expression (production) of metalloproteinases in leukocyte associated with metalloproteinase and rheumatoid arthritis
1) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.33 Pain Relevance 0.74

General Comments

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