INT176495

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.82
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP28) extracellular region (MMP28) proteinaceous extracellular matrix (MMP28)
Anatomy Link Frequency
cartilage 1
vessels 1
bladder 1
MMP28 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 108 100.00 Very High Very High Very High
rheumatoid arthritis 132 95.64 Very High Very High Very High
Inflammation 67 89.48 High High
Tendonitis 2 83.68 Quite High
Pain 6 82.56 Quite High
Osteoarthritis 17 80.44 Quite High
cytokine 32 55.44 Quite High
COX2 2 52.08 Quite High
agonist 4 50.00 Quite Low
Somatostatin 1 36.12 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 35 100.00 Very High Very High Very High
Bladder Cancer 29 99.84 Very High Very High Very High
Disease 28 96.16 Very High Very High Very High
Rheumatoid Arthritis 132 95.64 Very High Very High Very High
Carcinoma 2 92.68 High High
Apoptosis 13 92.64 High High
Osteoarthritis 35 91.64 High High
Syndrome 12 91.40 High High
INFLAMMATION 65 89.48 High High
Cancer 107 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study showed that MMP2, MT1-MMP, and MMP28 were very highly expressed in bladder tumour samples and MMP1, 7, 9, 11, 15, 19, and 23 were also highly expressed.
Gene_expression (expressed) of MMP28 in bladder associated with bladder cancer
1) Confidence 0.57 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.97 Pain Relevance 0.19
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Gene_expression (overexpressed) of MMP28 associated with adhesions
2) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.36 Pain Relevance 0
mediated cartilage breakdown by limiting MMP gene expression via a suppression of redox-regulated transcription factors like NF-?
Gene_expression (expression) of MMP gene in cartilage
3) Confidence 0.07 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.50 Pain Relevance 0.26
Specific inhibition of MMP gene synthesis is an alternative strategy for counteracting the overexpression of MMPs involved in particular diseases.
Gene_expression (synthesis) of MMP gene associated with metalloproteinase and disease
4) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 1.00 Pain Relevance 0.43
ligands target the same NHR complex and have similar inhibitory effects on MMP production, both ligands may be activating similar mechanisms to inhibit MMP gene expression.
Gene_expression (expression) of MMP gene
5) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.14 Pain Relevance 0.07
Regarding the regulation of MMP gene expression, the oncogene Ras (which upregulates MMP-1 and cathepsins) has been shown to colocalise with cathepsin L in the vessels of the RA synovium [126].
Gene_expression (expression) of MMP gene in vessels associated with rheumatoid arthritis and metalloproteinase
6) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.85 Pain Relevance 0.69

General Comments

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