INT1765

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Context Info
Confidence 0.51
First Reported 1979
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 140
Total Number 143
Disease Relevance 68.68
Pain Relevance 27.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
osteoblasts 28
chondrocytes 18
fibroblasts 12
keratinocytes 8
neutrophil 8
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2248 100.00 Very High Very High Very High
Inflammatory mediators 163 100.00 Very High Very High Very High
cytokine 898 99.98 Very High Very High Very High
Inflammatory stimuli 74 99.98 Very High Very High Very High
qutenza 7 99.98 Very High Very High Very High
bradykinin 6 99.96 Very High Very High Very High
Osteoarthritis 2732 99.84 Very High Very High Very High
Kinase C 39 99.76 Very High Very High Very High
COX2 76 99.26 Very High Very High Very High
cINOD 439 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2712 100.00 Very High Very High Very High
Influenza Virus Infection 311 100.00 Very High Very High Very High
Fever 93 100.00 Very High Very High Very High
Herpes Simplex Virus 952 99.98 Very High Very High Very High
Infection 686 99.98 Very High Very High Very High
Stress 172 99.90 Very High Very High Very High
Osteoarthritis 2796 99.84 Very High Very High Very High
Colorectal Cancer 72 99.84 Very High Very High Very High
Adenocarcinoma 305 99.82 Very High Very High Very High
Viral Infection 57 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although a novel promoter polymorphism (-765G > C) of COX-2 was not associated with AIA, the CC homozygote of this promoter polymorphism was associated with increased PGE2 production by creating an E2F transcription factor binding motif.27 Further studies are needed to clarify the role of COX-2 and PG imbalance in the pathogenic mechanisms of AIA in a Korean population.
Positive_regulation (increased) of Gene_expression (production) of PGE2 associated with asthma
1) Confidence 0.51 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.71 Pain Relevance 0.15
Human peripheral blood mononuclear cells produce a factor (MCF) that regularly stimulates the production of PGE2 and collagenase from resting ASC often by over 100-fold.
Positive_regulation (stimulates) of Gene_expression (production) of PGE2 in ASC
2) Confidence 0.39 Published 1979 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 231404 Disease Relevance 0.46 Pain Relevance 0.28
With respect to PGE2 receptors, CRC cells and their neighboring cells have augmented expression of receptors EP2 and EP4, while initially the EP3 receptor expression often is lowered [4,8,12-15], Figure 1.
Positive_regulation (augmented) of Gene_expression (expression) of EP2 in PGE2 associated with colorectal cancer
3) Confidence 0.33 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.77 Pain Relevance 0.41
Furthermore, an in vitro study performed on inflammatory cells demonstrated that eosinophils express high levels of EP2 and EP4 mRNA in comparison with EP1 and EP3, which were almost not present in these cells and that deficiency of PGE2 production may up-regulate the expression of EP2 and EP4 molecules [30].
Positive_regulation (levels) of Gene_expression (express) of EP2 in eosinophils associated with inflammation
4) Confidence 0.28 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.36 Pain Relevance 0.29
Basal expression of EP2 and EP4 receptors is increased on bronchial inflammatory cells from asthmatic patients and may be altered in vitro on eosinophils in response to inflammatory stimuli, suggesting the immunomodulatory role of these receptors in asthma, [15].
Positive_regulation (increased) of Gene_expression (expression) of EP2 in eosinophils associated with asthma, inflammation and inflammatory stimuli
5) Confidence 0.28 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.62 Pain Relevance 0.31
The predominant inhibitory effect of PGE2 in OA cartilage explants supports the notion that our previously observed suppression of collagen cleavage by TGF-?
Positive_regulation (effect) of Gene_expression (effect) of PGE2 in cleavage associated with osteoarthritis
6) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.42 Pain Relevance 0.26
Levels of PGE2 in the para-/auto-crine milieu are elevated in CRN [23-25] and the clinical benefits of reducing PGE2 levels for CRC has been documented [5,22,26-30].
Positive_regulation (elevated) of Gene_expression (Levels) of PGE2 associated with colorectal cancer
7) Confidence 0.27 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.60 Pain Relevance 0.13
TXA2 synthesis is immediate and dependent on cyclooxygenase Type 1 (COX-1) activity whereas PGE2 synthesis is delayed and dependent on COX-2 activity.
Positive_regulation (dependent) of Gene_expression (synthesis) of PGE2 in PGE2
8) Confidence 0.25 Published 2001 Journal Inflamm. Res. Section Abstract Doc Link 11409487 Disease Relevance 0.34 Pain Relevance 0.24
Activation of Ras leads to an upregulation of COX-2 resulting in increased PGE2 production [58].
Positive_regulation (increased) of Gene_expression (production) of PGE2 associated with fever
9) Confidence 0.22 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.98 Pain Relevance 0
COX-2 induction or overexpression is associated with an increased production of PGE2, one of the major products of COX-2 which is known to modulate cell proliferation, cell death, and tumor invasion in many types of cancer including colon, breast, and lung.
Positive_regulation (increased) of Gene_expression (production) of PGE2 in lung associated with cancer, fever and death
10) Confidence 0.22 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.39 Pain Relevance 0.22
In response to mechanical stretching, human PDL cells showed a marked elevation in PGE2 production in a time-dependent manner.
Positive_regulation (elevation) of Gene_expression (production) of PGE2 in PDL
11) Confidence 0.19 Published 1995 Journal J. Dent. Res. Section Abstract Doc Link 7560389 Disease Relevance 0.25 Pain Relevance 0.25
The increase in PGE2 production was significantly inhibited by laser irradiation in a dose-dependent manner.
Positive_regulation (increase) of Gene_expression (production) of PGE2
12) Confidence 0.19 Published 1995 Journal J. Dent. Res. Section Abstract Doc Link 7560389 Disease Relevance 0.23 Pain Relevance 0.23
Control experiments, in which medium was replaced by fresh PGE2-containing medium evidenced no obvious difference in the experimental outcome, arguing against PGE2 stability as a limiting factor. 12 hr prior to quenching the samples, 0,5 ?
Neg (no) Positive_regulation (arguing) of Gene_expression (stability) of PGE2
13) Confidence 0.19 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.06 Pain Relevance 0.11
In their study they monitored the effect of various concentrations of PGE2 on HT-29 proliferation 24 h or 48 h after PGE2 administration.
Positive_regulation (concentrations) of Gene_expression (administration) of PGE2 in HT-29
14) Confidence 0.19 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.50 Pain Relevance 0.08
Also in this case, the highest expression of the LH/hCG-R occurred during the luteal phase of the cycle, and paralleled an increased synthesis of PGE2.
Positive_regulation (increased) of Gene_expression (synthesis) of PGE2
15) Confidence 0.10 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.11 Pain Relevance 0
induces the expression of OPG and RANKL in human chondrocytes via an autocrine mechanism that increases PGE2 production.
Positive_regulation (increases) of Gene_expression (production) of PGE2 in chondrocytes
16) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.08 Pain Relevance 0
may promote the expression of EP4 by increasing PGE2 production in chondrocytes [23].
Positive_regulation (increasing) of Gene_expression (production) of PGE2 in chondrocytes
17) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.14 Pain Relevance 0.11
IM also enhanced TNF and suppressed IL-6 production, respectively, in both IL-2-activated PBMC and IL-2-dependent NK cell line, with the inhibition of their high levels of PGE2 production.
Positive_regulation (levels) of Gene_expression (production) of PGE2 in NK cell
18) Confidence 0.09 Published 1995 Journal Cytokine Section Abstract Doc Link 8589268 Disease Relevance 0.31 Pain Relevance 0.46
Moreover, inclusion of indomethacin caused a 20% reduction in IL-6 production and totally eliminated PGE2 production.
Positive_regulation (caused) of Gene_expression (production) of PGE2
19) Confidence 0.09 Published 1996 Journal J. Clin. Periodontol. Section Abstract Doc Link 8841895 Disease Relevance 0.17 Pain Relevance 0.24
increases the production of PGE2, COX-2, and EP4 receptor in the same chondrocytes as used in this study [23].
Positive_regulation (increases) of Gene_expression (production) of PGE2 in chondrocytes
20) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.18 Pain Relevance 0.14

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