INT176510

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 22.10
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
apoptotic cells 5
plasma 2
neck 1
cleavage 1
band 1
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 271 99.70 Very High Very High Very High
cytokine 123 95.80 Very High Very High Very High
Inflammatory response 55 94.88 High High
chemokine 30 87.88 High High
Angina 3 87.40 High High
rheumatoid arthritis 10 82.32 Quite High
metalloproteinase 8 67.44 Quite High
imagery 14 37.12 Quite Low
antagonist 8 32.44 Quite Low
fibrosis 95 24.48 Low Low
Disease Link Frequency Relevance Heat
Cancer 987 100.00 Very High Very High Very High
Apoptosis 277 100.00 Very High Very High Very High
Coronary Artery Disease 108 99.80 Very High Very High Very High
INFLAMMATION 318 99.70 Very High Very High Very High
Breast Cancer 187 99.56 Very High Very High Very High
Diabetes Mellitus 216 99.16 Very High Very High Very High
Carcinoma 77 99.16 Very High Very High Very High
Metastasis 671 98.92 Very High Very High Very High
Targeted Disruption 186 98.72 Very High Very High Very High
Disease 137 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in humans and human derived cell lines demonstrate that OPN is associated with both breast carcinoma and with metastatic breast carcinoma, and confirm that the breast cancer cells are a significant source of OPN expression [43].
OPN Binding (associated) of associated with breast cancer
1) Confidence 0.42 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.09 Pain Relevance 0
These studies, in humans and in animal models, demonstrate an association of OPN with breast/mammary carcinoma, and specifically with metastatic disease.
OPN Binding (association) of associated with carcinoma and metastasis
2) Confidence 0.42 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.90 Pain Relevance 0
OPN is known to bind to components of the extracellular matrix.
OPN Binding (bind) of in extracellular matrix
3) Confidence 0.42 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.77 Pain Relevance 0
Likewise, Zohar and colleagues have shown that OPN may bind with an ezrin–radixin–moesin complex (band 4.1 proteins) in cooperation with CD44, in order to stimulate cytoskeleton remodeling, signaling, and migration [51].
OPN Binding (bind) of in band
4) Confidence 0.42 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.31 Pain Relevance 0
After adjusting for age, the associations between plasma OPN and hsCRP (r = 0.383; P < 0.001) remained significant.
OPN Binding (associations) of in plasma
5) Confidence 0.37 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.09 Pain Relevance 0
Moreover, Kupffer cells as well as other phagocytes may be further activated (pro-inflammatory) by increased recognition of aPL-Ab bound to the surface of apoptotic cells through the IgG Fc receptors.
aPL Binding (recognition) of in apoptotic cells associated with inflammation and apoptosis
6) Confidence 0.36 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.41 Pain Relevance 0.25
Interestingly, as many as 60–80% of ALD patients with an advanced stage of the disease have significantly increased levels of anti-phospholipid autoantibodies (aPL-Ab) that recognize oxidized cardiolipin and phosphatidylserine (reviewed in [249]). aPL-Ab, by recognizing and binding to specifically oxidized epitopes in apoptotic hepatocytes (not in living cells, with phosphatidylserine being oxidized during apoptosis and before exposure on plasma membranes), may affect the ability of Kupffer cells to recognize and phagocytose apoptotic cells.
aPL Binding (recognizing) of in apoptotic cells associated with alcoholic liver diseases, apoptosis and disease
7) Confidence 0.36 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.25 Pain Relevance 0.26
Interestingly, as many as 60–80% of ALD patients with an advanced stage of the disease have significantly increased levels of anti-phospholipid autoantibodies (aPL-Ab) that recognize oxidized cardiolipin and phosphatidylserine (reviewed in [249]). aPL-Ab, by recognizing and binding to specifically oxidized epitopes in apoptotic hepatocytes (not in living cells, with phosphatidylserine being oxidized during apoptosis and before exposure on plasma membranes), may affect the ability of Kupffer cells to recognize and phagocytose apoptotic cells.
aPL Binding (recognize) of in apoptotic cells associated with alcoholic liver diseases, apoptosis and disease
8) Confidence 0.36 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.57 Pain Relevance 0.33
Interestingly, as many as 60–80% of ALD patients with an advanced stage of the disease have significantly increased levels of anti-phospholipid autoantibodies (aPL-Ab) that recognize oxidized cardiolipin and phosphatidylserine (reviewed in [249]). aPL-Ab, by recognizing and binding to specifically oxidized epitopes in apoptotic hepatocytes (not in living cells, with phosphatidylserine being oxidized during apoptosis and before exposure on plasma membranes), may affect the ability of Kupffer cells to recognize and phagocytose apoptotic cells.
aPL Binding (binding) of in apoptotic cells associated with alcoholic liver diseases, apoptosis and disease
9) Confidence 0.36 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.31 Pain Relevance 0.29
Interestingly, as many as 60–80% of ALD patients with an advanced stage of the disease have significantly increased levels of anti-phospholipid autoantibodies (aPL-Ab) that recognize oxidized cardiolipin and phosphatidylserine (reviewed in [249]). aPL-Ab, by recognizing and binding to specifically oxidized epitopes in apoptotic hepatocytes (not in living cells, with phosphatidylserine being oxidized during apoptosis and before exposure on plasma membranes), may affect the ability of Kupffer cells to recognize and phagocytose apoptotic cells.
aPL Binding (recognize) of in apoptotic cells associated with alcoholic liver diseases, apoptosis and disease
10) Confidence 0.35 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.25 Pain Relevance 0.27
We interpret these results, as well as our results, to indicate that additional PI3-K-related genes are required to functionally interact with OPN to produce the fully metastatic phenotype.
OPN Binding (interact) of
11) Confidence 0.33 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.31 Pain Relevance 0
Immunohistochemical staining for OPN in Met tumors and Db tumors
OPN Binding (staining) of associated with cancer
12) Confidence 0.33 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.51 Pain Relevance 0
The enzyme bound to OPN was visualized using an enhanced chemiluminescence detection kit (ECL; AP Biotech, Piscataway, NJ, USA).
OPN Binding (bound) of
13) Confidence 0.33 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.30 Pain Relevance 0
To observe a more direct association of OPN and metastatic potential, we used our model system, with its metastatic line and a nonmetastatic line, to manipulate OPN expression by overexpressing it in the nonmetastatic line and by abrogating its expression in the metastatic line, and observing whether the presence or absence of OPN can affect the phenotype with regard to metastasis.
OPN Binding (association) of associated with metastasis
14) Confidence 0.33 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.83 Pain Relevance 0
As a group, Met tumors showed diffuse cytoplasmic OPN staining with more intense staining in the peripheral areas of the tumor.
OPN Binding (group) of associated with cancer
15) Confidence 0.33 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.81 Pain Relevance 0
Extracellular OPN and intracellular OPN were found by immunohistochemistry.
OPN Binding (found) of
16) Confidence 0.33 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.82 Pain Relevance 0
Extracellular OPN and intracellular OPN were found by immunohistochemistry.
OPN Binding (found) of
17) Confidence 0.33 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.82 Pain Relevance 0
In addition, we demonstrated a significant association between plasma OPN levels and the presence and severity of CAD in diabetic patients, indicating that OPN may be critically involved in the inflammatory processes that take place within the vascular wall in diabetes.


OPN Binding (association) of in plasma associated with coronary artery disease, inflammation and diabetes mellitus
18) Confidence 0.32 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.77 Pain Relevance 0.31
Unexpectedly, there was no association between N-half OPN and CAD or hsCRP in diabetic patients.
OPN Neg (no) Binding (association) of associated with coronary artery disease and diabetes mellitus
19) Confidence 0.32 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.47 Pain Relevance 0.28
The new insights on the role of thrombin and tcOPN as well as the well characterized binding of the latter to the integrins ?
tcOPN Binding (binding) of
20) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox