INT176513

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 4.32
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
bone tissue 1
osteoblast 1
osteoclast 1
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 74 94.88 High High
cytokine 12 91.80 High High
chemokine 4 89.00 High High
Inflammation 65 81.76 Quite High
rheumatoid arthritis 5 63.28 Quite High
antagonist 7 18.24 Low Low
Versed 1 14.24 Low Low
Bile 39 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 172 100.00 Very High Very High Very High
Osteogenic Sarcomas 5 99.56 Very High Very High Very High
Hyperoxia 49 99.02 Very High Very High Very High
Cardiovascular Disorder Under Development 56 94.88 High High
Tibial Fractures 10 93.40 High High
Stress 11 92.60 High High
Fracture Healing 65 92.48 High High
Coronary Heart Disease 28 91.08 High High
INFLAMMATION 58 81.76 Quite High
Fibrosis 18 79.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, p38 and ERK directly increase OPN transcription [55,56].
Transcription (transcription) of OPN
1) Confidence 0.63 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.42 Pain Relevance 0
AMCMs had more than a fivefold increase in OPN mRNA expression versus cPPAR?
Transcription (expression) of OPN
2) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.21 Pain Relevance 0.36
No significant differences in the mRNA levels for OPN, BSP, TRAP, or CTK between the groups or between the different time points were detected (Table 4).
Transcription (levels) of OPN
3) Confidence 0.15 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.16 Pain Relevance 0
In OVX-D rats at 3 weeks relative to 6 weeks, there was a significant decline in the ratio of cells expressing mRNA for OPN, BSP, and CTK but not that for TRAP.
Neg (not) Transcription (expressing) of OPN
4) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.23 Pain Relevance 0
No significant differences were found for the overall quantitative immunogold distribution of OPN and BSP, with respect to either groups or time points (Table 6).
Transcription (distribution) of OPN
5) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0 Pain Relevance 0
Vitamin K2 treatment of osteosarcoma cells increased mRNA levels for the osteoblast markers bone alkaline phosphatase, osteoprotegerin, osteopontin and matrix Gla protein.
Transcription (levels) of osteopontin in osteoblast associated with osteoporosis and osteogenic sarcomas
6) Confidence 0.12 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.69 Pain Relevance 0
mRNA expression for OPN, BSP, TRAP, and CTK in cell types was distributed as previously described in intact bone tissue [21, 26, 43].
Transcription (expression) of OPN in bone tissue
7) Confidence 0.11 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.40 Pain Relevance 0.03
To test this hypothesis, we examined global gene expression and in situ mRNA expression as well as the ultrastructural protein distribution of two major phosphoproteins in bone, i.e., osteopontin (OPN) and bone sialoprotein (BSP), and two osteoclast enzymes, i.e., tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CTK), in the callus 3 and 6 weeks after tibial fracture of vitamin D-depleted OVX rats.
Transcription (expression) of OPN in osteoclast associated with tibial fractures
8) Confidence 0.11 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.54 Pain Relevance 0
On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).
Transcription (concentrations) of OPN associated with hyperoxia
9) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.68 Pain Relevance 0.28

General Comments

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