INT176517

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 15.31
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
macrophages 4
uterus 2
fat pad 2
node 2
lungs 2
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 219 100.00 Very High Very High Very High
Acupuncture 45 99.98 Very High Very High Very High
Inflammation 167 99.42 Very High Very High Very High
agonist 6 99.24 Very High Very High Very High
Inflammatory response 12 97.36 Very High Very High Very High
cytokine 187 89.56 High High
Dopamine 122 87.76 High High
imagery 14 35.96 Quite Low
chemokine 14 25.52 Quite Low
Neuropeptide 1 12.64 Low Low
Disease Link Frequency Relevance Heat
Disease 247 100.00 Very High Very High Very High
Cardiovascular Disorder Under Development 168 100.00 Very High Very High Very High
Targeted Disruption 148 100.00 Very High Very High Very High
Parkinson's Disease 41 100.00 Very High Very High Very High
Neurodegenerative Disease 34 100.00 Very High Very High Very High
Urological Neuroanatomy 7 100.00 Very High Very High Very High
Stroke 7 100.00 Very High Very High Very High
Fibrosis 54 99.92 Very High Very High Very High
Cancer 979 99.80 Very High Very High Very High
Breast Cancer 187 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the Met lines, using antisense methodology, we were able to significantly decrease the OPN protein expression to nearly undetectable levels.
Negative_regulation (decrease) of Gene_expression (expression) of OPN protein
1) Confidence 0.59 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.57 Pain Relevance 0
This decrease in OPN protein expression was associated with a threefold decrease in the number of cells that migrated, as compared with the vector-transfected Met control.
Negative_regulation (decrease) of Gene_expression (expression) of OPN protein
2) Confidence 0.59 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.52 Pain Relevance 0
Immunoblot analysis of detergent lysates demonstrated that OPN antisense expression in Met markedly reduced basal OPN expression to barely detectable levels, similar to that observed in the Db vector control (Fig. 5a).
Negative_regulation (antisense) of Gene_expression (expression) of OPN
3) Confidence 0.51 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0 Pain Relevance 0
In in vivo tail vein and mammary fat pad injection experiments, this decrease in OPN expression was associated with an elimination of metastatic ability.
Negative_regulation (decrease) of Gene_expression (expression) of OPN in fat pad associated with peripheral arterial disease
4) Confidence 0.51 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.45 Pain Relevance 0
This is demonstrated by the Met-As cells, in which OPN expression is nearly completely abolished.
Negative_regulation (abolished) of Gene_expression (expression) of OPN
5) Confidence 0.51 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.29 Pain Relevance 0
OPN transcript expression in Met and Db cell lines and tumors
Negative_regulation (lines) of Gene_expression (expression) of OPN transcript associated with cancer
6) Confidence 0.43 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.85 Pain Relevance 0
ligands are insulin sensitizers and have profound anti-inflammatory effects, one of which is to decrease OPN expression in vascular and renal cells (16).
Negative_regulation (decrease) of Gene_expression (expression) of OPN associated with inflammation
7) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.56 Pain Relevance 0.45
In addition, it has been shown, by immunohistochemistry and in situ hybridization, that OPN expression is associated with decreased disease survival and decreased overall survival in node-negative breast cancer [40].
Negative_regulation (decreased) of Gene_expression (expression) of OPN in node associated with breast cancer and disease
8) Confidence 0.38 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.09 Pain Relevance 0
In order to test this hypothesis, we generated Met sublines and Db sublines having suppressed or enforced expression of OPN, respectively.
Negative_regulation (suppressed) of Gene_expression (expression) of OPN
9) Confidence 0.38 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.06 Pain Relevance 0
However, in the Met-As cells, where the PI3-K binding component of PyV-mT is not altered, the loss of metastatic ability can be directly attributed to the suppression of OPN expression.
Negative_regulation (suppression) of Gene_expression (expression) of OPN
10) Confidence 0.38 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.59 Pain Relevance 0
Studies in humans and human derived cell lines demonstrate that OPN is associated with both breast carcinoma and with metastatic breast carcinoma, and confirm that the breast cancer cells are a significant source of OPN expression [43].
Negative_regulation (source) of Gene_expression (expression) of OPN associated with breast cancer
11) Confidence 0.37 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.13 Pain Relevance 0
Immunoblot analysis of detergent lysates demonstrated that OPN antisense expression in Met markedly reduced basal OPN expression to barely detectable levels, similar to that observed in the Db vector control (Fig. 5a).
Negative_regulation (reduced) of Gene_expression (expression) of OPN
12) Confidence 0.37 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0 Pain Relevance 0
0.10) and significantly diminished MPO levels in OPN KO lungs at 72 h after infection (figure 4I, P<0.05).


Negative_regulation (diminished) of Gene_expression (lungs) of OPN in lungs associated with targeted disruption, urological neuroanatomy and infection
13) Confidence 0.37 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 2.81 Pain Relevance 0.20
agonists can attenuate myocardial fibrosis by reducing OPN expression in cardiomyocytes and/or macrophages, thereby decreasing cardiac inflammatory responses that can result in fibrosis.
Negative_regulation (reducing) of Gene_expression (expression) of OPN in macrophages associated with fibrosis, inflammatory response and agonist
14) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.57 Pain Relevance 0.47
Pioglitazone decreased cardiac fibrosis, macrophage accumulation, and OPN expression in cPPAR??
Negative_regulation (decreased) of Gene_expression (expression) of OPN in macrophage associated with fibrosis and cardiovascular disorder under development
15) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 0.98 Pain Relevance 0.39
Osteopontin expression was depressed and procalcifying alkaline phosphatase specific activity and calcification were markedly upregulated in cultured NPP1-/- SMCs [35].
Negative_regulation (depressed) of Gene_expression (expression) of Osteopontin associated with calcification
16) Confidence 0.17 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.45 Pain Relevance 0
Similarly, Moran and colleagues [130] reported that the expression levels of osteopontin, a secretory phosphoprotein with antiapoptotic properties that can attenuate the neurodegenerative consequences of stroke [136] and MPTP (at least in common marmosets) [137], were suppressed in IFN-?
Negative_regulation (suppressed) of Gene_expression (expression) of osteopontin associated with parkinson's disease, stroke and neurodegenerative disease
17) Confidence 0.08 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 1.06 Pain Relevance 0.31
Similarly, Moran and colleagues [130] reported that the expression levels of osteopontin, a secretory phosphoprotein with antiapoptotic properties that can attenuate the neurodegenerative consequences of stroke [136] and MPTP (at least in common marmosets) [137], were suppressed in IFN-?
Negative_regulation (suppressed) of Gene_expression (levels) of osteopontin associated with parkinson's disease, stroke and neurodegenerative disease
18) Confidence 0.08 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 1.06 Pain Relevance 0.31
The present study showed that AC improved the expression of LIF and OPN proteins in a rat's uterus during implantation period.
Negative_regulation (improved) of Gene_expression (expression) of OPN in uterus associated with acupuncture
19) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2957198 Disease Relevance 0.30 Pain Relevance 0.15

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