INT176518

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.36
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
osteoblast 4
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 38 93.72 High High
chemokine 12 90.92 High High
Inflammation 47 83.68 Quite High
Tendonitis 1 10.24 Low Low
cINOD 2 5.52 Low Low
alcohol 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 60 100.00 Very High Very High Very High
Hyperoxia 49 99.98 Very High Very High Very High
Bacterial Infection 5 99.96 Very High Very High Very High
Metastasis 61 97.92 Very High Very High Very High
Fungal Infection 1 97.08 Very High Very High Very High
Infection 42 95.88 Very High Very High Very High
Calcification 2 95.72 Very High Very High Very High
Melioidosis 57 84.52 Quite High
INFLAMMATION 39 83.68 Quite High
Cancer 89 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of calcium nodules concomitant with the increase of ALP activity and the activation of the Opn gene showed that the respective cells had differentiated into matured osteoblasts.
Positive_regulation (increase) of Positive_regulation (activation) of Opn in osteoblasts
1) Confidence 0.47 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.24 Pain Relevance 0
Enhanced OPN production is not likely to be restricted to bacterial infections: elevated circulating OPN levels have previously been reported in patients with mycobacterial and fungal infections [35]–[38].
Positive_regulation (elevated) of Positive_regulation (elevated) of OPN associated with fungal infection and bacterial infection
2) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.90 Pain Relevance 0
Db cells with enforced overexpression of OPN showed elevated levels of OPN but did not demonstrate an increase in the rate of metastasis compared with the wild-type Db cells.


Positive_regulation (elevated) of Positive_regulation (levels) of OPN associated with metastasis
3) Confidence 0.41 Published 2004 Journal Breast Cancer Res Section Abstract Doc Link PMC400667 Disease Relevance 1.26 Pain Relevance 0
The osteoplant causes induction of osteoblast transcriptional factors such as osterix (RUNX2), and of bone-related genes such as osteopontin (SPP1) and osteocalcin (BGLAP).
Positive_regulation (causes) of Positive_regulation (induction) of osteopontin in osteoblast associated with osteoporosis
4) Confidence 0.27 Published 2010 Journal Journal of Indian Society of Periodontology Section Abstract Doc Link PMC2933523 Disease Relevance 0.28 Pain Relevance 0
On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).
Positive_regulation (induced) of Positive_regulation (increase) of OPN associated with hyperoxia
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.69 Pain Relevance 0.28

General Comments

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