INT176518

Context Info Confidence 0.47 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 3.36 Pain Relevance 0.28

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1) cytoplasm (Spp1)

Anatomy Link Frequency osteoblast 4 Spp1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 38 93.72 chemokine 12 90.92 Inflammation 47 83.68 Tendonitis 1 10.24 cINOD 2 5.52 alcohol 3 5.00 Inflammatory response 2 5.00 Lasting pain 1 5.00 Central nervous system 1 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Osteoporosis 60 100.00 Hyperoxia 49 99.98 Bacterial Infection 5 99.96 Metastasis 61 97.92 Fungal Infection 1 97.08 Infection 42 95.88 Calcification 2 95.72 Melioidosis 57 84.52 INFLAMMATION 39 83.68 Cancer 89 81.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The presence of calcium nodules concomitant with the increase of ALP activity and the activation of the Opn gene showed that the respective cells had differentiated into matured osteoblasts.

Positive_regulation (increase) of Positive_regulation (activation) of Opn in osteoblasts

1) Confidence 0.47 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.24 Pain Relevance 0

Enhanced OPN production is not likely to be restricted to bacterial infections: elevated circulating OPN levels have previously been reported in patients with mycobacterial and fungal infections [35]–[38].

Positive_regulation (elevated) of Positive_regulation (elevated) of OPN associated with fungal infection and bacterial infection

2) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.90 Pain Relevance 0

Db cells with enforced overexpression of OPN showed elevated levels of OPN but did not demonstrate an increase in the rate of metastasis compared with the wild-type Db cells.

Positive_regulation (elevated) of Positive_regulation (levels) of OPN associated with metastasis

3) Confidence 0.41 Published 2004 Journal Breast Cancer Res Section Abstract Doc Link PMC400667 Disease Relevance 1.26 Pain Relevance 0

The osteoplant causes induction of osteoblast transcriptional factors such as osterix (RUNX2), and of bone-related genes such as osteopontin (SPP1) and osteocalcin (BGLAP).

Positive_regulation (causes) of Positive_regulation (induction) of osteopontin in osteoblast associated with osteoporosis

4) Confidence 0.27 Published 2010 Journal Journal of Indian Society of Periodontology Section Abstract Doc Link PMC2933523 Disease Relevance 0.28 Pain Relevance 0

On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).

Positive_regulation (induced) of Positive_regulation (increase) of OPN associated with hyperoxia

5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.69 Pain Relevance 0.28

General Comments

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