INT176519

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 8.54
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
plasma 2
osteoblast 2
extracellular matrix 2
lung 2
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 30 92.76 High High
Inflammation 30 89.84 High High
cytokine 38 47.84 Quite Low
chemokine 8 28.96 Quite Low
imagery 2 28.88 Quite Low
Tendonitis 1 23.60 Low Low
alcohol 6 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 57 100.00 Very High Very High Very High
Urological Neuroanatomy 7 100.00 Very High Very High Very High
Osteoporosis 47 99.84 Very High Very High Very High
Cancer 178 99.80 Very High Very High Very High
Renal Disease 27 99.80 Very High Very High Very High
Syndrome 2 99.74 Very High Very High Very High
Calcification 93 99.54 Very High Very High Very High
Coronary Artery Disease 36 99.16 Very High Very High Very High
Diabetes Mellitus 71 99.08 Very High Very High Very High
Disease 24 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other studies have reported that Opn expression is modulated by osteoblast stimulation in vivo, resulting in dramatically increased Opn [17,29].
Regulation (modulated) of Gene_expression (expression) of Opn in osteoblast associated with osteoporosis
1) Confidence 0.58 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.43 Pain Relevance 0
With respect to OPN expression, transcript levels were fourfold higher in the Met tumor versus the Db tumor.
Regulation (higher) of Gene_expression (expression) of OPN associated with cancer
2) Confidence 0.39 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.01 Pain Relevance 0
In addition, the primary tumors remained positive for the expression of OPN, as demonstrated by immunohistochemical analysis.
Regulation (positive) of Gene_expression (expression) of OPN associated with cancer
3) Confidence 0.39 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.56 Pain Relevance 0
Relationship between plasma OPN levels and nephropathy and CAD in diabetes
Regulation (plasma) of Gene_expression (levels) of OPN in plasma associated with coronary artery disease, diabetes mellitus and renal disease
4) Confidence 0.39 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.48 Pain Relevance 0
In accordance with the results on reduced percentages of affected lung, we found a trend towards reduced MPO levels in OPN KO lungs at 24 h (P?
Regulation (trend) of Gene_expression (lungs) of OPN in lung associated with targeted disruption and urological neuroanatomy
5) Confidence 0.39 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 2.86 Pain Relevance 0.24
PPi is a central regulator of calcification in the extracellular matrix, but extracellular PPi regulates gene expression and cellular differentiation, including major physiologic effects on chondrogenesis and expression of osteopontin.
Regulation (effects) of Gene_expression (expression) of osteopontin in extracellular matrix associated with calcification
6) Confidence 0.24 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.38 Pain Relevance 0.05
NPP1 and PPi metabolism in pathologic soft tissue calcification syndromes and pivotal role of osteopontin depletion
Regulation (role) of Gene_expression (depletion) of osteopontin associated with calcification and syndrome
7) Confidence 0.18 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.83 Pain Relevance 0.06

General Comments

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