INT176521

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.60
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lepr) extracellular space (Lepr) extracellular region (Lepr)
plasma membrane (Lepr)
Anatomy Link Frequency
T cell 2
fat pad 1
Lepr (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 45 50.24 Quite High
ketamine 4 25.04 Quite Low
aspirin 84 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
alcohol 15 5.00 Very Low Very Low Very Low
peripheral neuropathy 15 5.00 Very Low Very Low Very Low
Calcium channel 12 5.00 Very Low Very Low Very Low
depression 12 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1590 100.00 Very High Very High Very High
Metastasis 244 100.00 Very High Very High Very High
Peripheral Arterial Disease 65 100.00 Very High Very High Very High
Gestational Diabetes 45 99.68 Very High Very High Very High
Influenza Virus Infection 126 94.48 High High
Congenital Anomalies 27 91.00 High High
Cancer 352 86.96 High High
Infection 72 84.16 Quite High
Body Weight 30 72.08 Quite High
Obesity 42 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such a combination of priming and challenge viruses offers an unique opportunity to dissect the impact of NP366/Db epitope sequence variation on memory CD8 T cell-mediated protective heterotypic immunity in B6 mice.
Positive_regulation (variation) of Db in T cell
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868023 Disease Relevance 0.76 Pain Relevance 0
Decreased capacity of the heterosubtypic immunity is correlated with significantly reduced magnitude of the cross-reactive memory CD8 T cell response to the NP366/Db variants
Positive_regulation (response) of Db in T cell
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868023 Disease Relevance 0.60 Pain Relevance 0
Conversely, OPN expression was successfully elevated in Db-S.
Positive_regulation (elevated) of Db-S
3) Confidence 0.04 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0 Pain Relevance 0
As a group, the Met-As clones showed decreased migration, while the Db-S clones showed an increase in its migration capacity.
Positive_regulation (increase) of Db-S
4) Confidence 0.03 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.05 Pain Relevance 0
The observation that there was no increase in the metastasis rate in the fat pad experiments in the Db-S line, despite increased OPN expression and the increased migration of the cells in vitro, was surprising.
Neg (no) Positive_regulation (increase) of Db-S in fat pad associated with peripheral arterial disease and metastasis
5) Confidence 0.03 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.51 Pain Relevance 0
However, the Db-S cells, with elevated OPN levels, showed no increase in the metastasis rate when compared with the wild-type Db cells.
Positive_regulation (elevated) of Db-S associated with metastasis
6) Confidence 0.02 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.88 Pain Relevance 0
Because women with a history of GDM have a greatly increased subsequent risk for diabetes (28), they should be screened for diabetes 6–12 weeks postpartum, using nonpregnant OGTT criteria, and should be followed up with subsequent screening for the development of diabetes or pre-diabetes, as outlined in II.
Positive_regulation (increased) of diabetes associated with diabetes mellitus and gestational diabetes
7) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 1.36 Pain Relevance 0.03
Testing for diabetes will also detect individuals at increased future risk for diabetes, herein referred to as pre-diabetic.


Positive_regulation (increased) of diabetes associated with diabetes mellitus
8) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 1.62 Pain Relevance 0
Planned pregnancies greatly facilitate preconception diabetes care.
Positive_regulation (facilitate) of diabetes associated with diabetes mellitus
9) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.82 Pain Relevance 0

General Comments

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